Approaches for the discovery of drugs that target K Na 1.1 channels in KCNT1-associated epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2150164
Abstract: ABSTRACT Introduction There are approximately 70 million people with epilepsy and about 30% of patients are not satisfactorily treated. A link between gene mutations and epilepsy is well documented. A number of pathological variants of… read more here.
Keywords: gene mutations; discovery drugs; approaches discovery; kcnt1 gene ... See more keywords
Abstract CN03-01: Functional genomics approaches to the discovery of paralog dependencies in cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-cn03-01
Abstract: Advances in next-generation sequencing and projects including the Cancer Genome Anatomy project and the International Cancer Genome Consortium have given us a detailed description of the genetic alterations across a broad spectrum of cancer. This… read more here.
Keywords: genomics approaches; cancer; paralog dependencies; cell ... See more keywords
Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26154582
Abstract: Biofilms, the predominant growth mode of microorganisms, pose a significant risk to human health. The protective biofilm matrix, typically composed of exopolysaccharides, proteins, nucleic acids, and lipids, combined with biofilm-grown bacteria’s heterogenous physiology, leads to… read more here.
Keywords: discovery small; strategies approaches; small molecule; physiology ... See more keywords