The current and emerging therapeutic approaches in drug-resistant epilepsy management
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neurologica Belgica"
DOI: 10.1007/s13760-019-01120-8
Abstract: Epilepsy is a neurologic disorder consisting of recurrent spontaneous seizures. Antiepileptic drugs administration is the most commonly used therapeutic strategy in the management of epilepsy. However, 20–30% of epilepsy patients have seizure episodes that are… read more here.
Keywords: epilepsy; therapeutic approaches; resistant epilepsy; drug resistant ... See more keywords
Novel Approaches, Drug Candidates, and Targets in Pain Drug Discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00028
Abstract: Because of the problems associated with opioids, drug discovery efforts have been employed to develop opioids with reduced side effects using approaches such as biased opioid agonism, multifunctional opioids, and allosteric modulation of opioid receptors.… read more here.
Keywords: novel approaches; drug; drug discovery; novel analgesics ... See more keywords
Approaches to drug monitoring: partnering with the clinical laboratory.
Sign Up to like & getrecommendations! Published in 2020 at "International Anesthesiology Clinics"
DOI: 10.1097/aia.0000000000000269
Abstract: Mr X has been referred to the transplant center for liver transplant evaluation secondary to end-stage liver disease of unknown etiology. His medical history is significant for previous illicit opioid use after a tragic work-related… read more here.
Keywords: toxicology; approaches drug; laboratory; drug ... See more keywords
Abstract IA05: Genomic approaches to drug discovery
Sign Up to like & getrecommendations! Published in 2018 at "Omics A Journal of Integrative Biology"
DOI: 10.1158/1557-3265.sarcomas17-ia05
Abstract: It is now becoming possible to bring powerful genomic methods to bear on the process of drug discovery. This talk will illustrate 1) the use of the Connectivity Map, a large-scale effort to develop a… read more here.
Keywords: abstract ia05; drug; discovery; genomic approaches ... See more keywords
Computational approaches for drug repurposing in oncology: untapped opportunity for high value innovation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1198284
Abstract: Historically, the effort by academia and industry to develop new chemical entities into lifesaving drugs has limited success in meeting the demands of today’s healthcare. Repurposing drugs that are originally approved by the United States… read more here.
Keywords: oncology; computational approaches; approaches drug; drug repurposing ... See more keywords
Computational Approaches for Drug Discovery
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24173061
Abstract: Computational approaches represent valuable and essential tools in each step of the drug discovery and development trajectory [...]. read more here.
Keywords: drug discovery; computational approaches; approaches drug;