Multi-Omic Approaches to Identify Genetic Factors in Metabolic Syndrome.
Sign Up to like & getrecommendations! Published in 2021 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210010
Abstract: Metabolic syndrome (MetS) is a highly heritable disease and a major public health burden worldwide. MetS diagnosis criteria are met by the simultaneous presence of any three of the following: high triglycerides, low HDL/high LDL… read more here.
Keywords: complex disease; omic approaches; approaches identify; disease ... See more keywords
Fragment-Based Approaches to Identify RNA Binders.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00034
Abstract: Although fragment-based drug discovery (FBDD) has been successfully implemented and well-explored for protein targets, its feasibility for RNA targets is emerging. Despite the challenges associated with the selective targeting of RNA, efforts to integrate known… read more here.
Keywords: fragment based; identify rna; rna binders; based approaches ... See more keywords
Different chemical proteomic approaches to identify the targets of lapatinib
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2183809
Abstract: Abstract The process of identifying the protein targets and off-targets of a biologically active compound is of great importance in modern drug discovery. Various chemical proteomics approaches have been established for this purpose. To compare… read more here.
Keywords: different chemical; identify targets; chemical proteomic; chemistry ... See more keywords
Proteomic approaches to identify blood-based biomarkers for depression and bipolar disorders
Sign Up to like & getrecommendations! Published in 2018 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2018.1444483
Abstract: ABSTRACT Introduction: Major depressive disorder (MDD) and bipolar disorder (BD) are leading causes of disability worldwide, yet many people remain undiagnosed, are misdiagnosed, and/or ineffectively treated. Diagnosis relies on the clinical assessment of symptoms, and… read more here.
Keywords: approaches identify; identify blood; proteomic approaches; blood ... See more keywords
In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes
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DOI: 10.3390/biom11121877
Abstract: Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors, and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α-amylase enzymes inhibitors can suppress peaks of postprandial glucose with… read more here.
Keywords: identify polyphenol; type diabetes; glucosidase amylase; silico approaches ... See more keywords
Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19010574
Abstract: Exposure to Endocrine Disrupting Chemicals (EDC) has been linked with several adverse outcomes. In this review, we examine EDCs that are pervasive in the environment and are of concern in the context of human, animal,… read more here.
Keywords: toxicology; bioinformatics approaches; genomic bioinformatics; adverse outcomes ... See more keywords
Ribonomics Approaches to Identify RBPome in Plants and Other Eukaryotes: Current Progress and Future Prospects
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23115923
Abstract: RNA-binding proteins (RBPs) form complex interactions with RNA to regulate the cell’s activities including cell development and disease resistance. RNA-binding proteome (RBPome) aims to profile and characterize the RNAs and proteins that interact with each… read more here.
Keywords: identify rbpome; plants eukaryotes; eukaryotes current; rbpome plants ... See more keywords