Synthetic Approaches to Novel Human Carbonic Anhydrase Isoform Inhibitors Based on Pyrrol-2-one Moiety
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DOI: 10.1021/acs.jmedchem.3c02190
Abstract: New dihydro-pyrrol-2-one compounds, featuring dual sulfonamide groups, were synthesized through a one-pot, three-component approach utilizing trifluoroacetic acid as a catalyst. Computational analysis using density functional theory (DFT) and condensed Fukui function explored the structure–reactivity relationship.… read more here.
Keywords: carbonic anhydrase; approaches novel; synthetic approaches; human carbonic ... See more keywords