Experimental design approaches to optimize ultrasound-assisted simultaneous-silylation dispersive liquid–liquid microextraction for the rapid determination of parabens in water samples
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DOI: 10.1039/d1ra04195a
Abstract: This work describes a rapid solvent-minimized process to effectively determine four common paraben preservatives (methyl-, ethyl-, propyl- and butyl-paraben) in surface water samples. read more here.
Keywords: liquid; approaches optimize; experimental design; water samples ... See more keywords
Machine learning approaches to optimize small-molecule inhibitors for RNA targeting
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DOI: 10.1186/s13321-022-00583-x
Abstract: In the era of data science, data-driven algorithms have emerged as powerful platforms that can consolidate bioisosteric rules for preferential modifications on small molecules with a common molecular scaffold. Here we present complementary data-driven algorithms… read more here.
Keywords: small molecule; approaches optimize; optimize small; machine learning ... See more keywords
Biotechnological Approaches to Optimize the Production of Amaryllidaceae Alkaloids
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DOI: 10.3390/biom12070893
Abstract: Amaryllidaceae alkaloids (AAs) are plant specialized metabolites with therapeutic properties exclusively produced by the Amaryllidaceae plant family. The two most studied representatives of the family are galanthamine, an acetylcholinesterase inhibitor used as a treatment of… read more here.
Keywords: biotechnological approaches; optimize production; approaches optimize; production ... See more keywords