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Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2077328
Abstract: ABSTRACT Introduction Several decades of antitubercular drug discovery efforts have focused on novel antitubercular chemotherapies. However, recent efforts have greatly shifted toward countering extremely/multi/total drug-resistant species. Targeting the conditionally essential elements inside Mycobacterium is a…
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Keywords:
drug discovery;
iron;
approaches targeting;
conditionally essential ... See more keywords
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Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/1212369
Abstract: B-cell lymphoma 2 (Bcl-2) is a regulator protein involved in apoptosis. In the past few decades, this protein has been demonstrated to have high efficacy in cancer therapy, and several approaches targeting Bcl-2 have been…
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Keywords:
protein;
approaches targeting;
bcl inhibitors;
review ... See more keywords
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Published in 2019 at "SLAS Discovery"
DOI: 10.1177/2472555218818065
Abstract: RNA-binding proteins (RBPs) are pleiotropic factors that control the processing and functional compartmentalization of transcripts by binding primarily to mRNA untranslated regions (UTRs). The competitive and/or cooperative interplay between RBPs and an array of coding…
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Keywords:
targeting ribonucleoprotein;
screening approaches;
approaches targeting;
rna ... See more keywords
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Published in 2021 at "Molecular Medicine"
DOI: 10.1186/s10020-021-00423-y
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because…
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Keywords:
perspectives potential;
approaches targeting;
sars cov;
targeting neuropilin ... See more keywords
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Published in 2021 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2021010069
Abstract: Ischemia reperfusion injury (IRI) is the most common cause of in-hospital acute kidney injury and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the…
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Keywords:
signalling early;
approaches targeting;
iri;
recent approaches ... See more keywords
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Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170810165302
Abstract: Cysteine proteases are essential hydrolytic enzymes present in the majority of organisms, including viruses and unicellular parasites. Despite the high sequence identity displayed among these proteins, specific structural features across different species grant distinct functions…
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Keywords:
based approaches;
structure based;
approaches targeting;
cysteine proteases ... See more keywords
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Published in 2022 at "Current drug targets"
DOI: 10.2174/1389450123666220928152743
Abstract: The objective of this paper is to look at how natural medicines can improve cognition and memory when used with sildenafil, a popular erectile dysfunction medicine that also has nootropic properties. Newer treatment strategies to…
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Keywords:
targeting cognitive;
combinatory approaches;
approaches targeting;
review combinatory ... See more keywords
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Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.870049
Abstract: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. With the rising prevalence of diabetes, the occurrence of DN is likely to hit pandemic proportions. The current treatment strategies employed for DN…
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Keywords:
technological approaches;
kidney diseases;
targeting kidney;
approaches targeting ... See more keywords
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Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12030392
Abstract: Tumor-associated macrophages (TAMs) promote tumor proliferation, invasion, angiogenesis, stemness, therapeutic resistance, and immune tolerance in a protein-dependent manner. Therefore, the traditional target paradigms are often insufficient to exterminate tumor cells. These pro-tumoral functions are mediated…
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Keywords:
anti tumor;
approaches targeting;
associated macrophages;
therapeutic approaches ... See more keywords
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Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21031105
Abstract: Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury such as severe burns, trauma, and major surgeries. Pathologic skin fibrosis results in scars that are disfiguring, limit normal movement, and prevent patient recovery…
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Keywords:
wound healing;
fibrosis;
targeting wound;
approaches targeting ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042155
Abstract: The treatment of lung infection in the context of cystic fibrosis (CF) is limited by a biofilm mode of growth of pathogenic organisms. When compared to planktonically grown bacteria, bacterial biofilms can survive extremely high…
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Keywords:
cystic fibrosis;
bacterial biofilms;
targeting bacterial;
approaches targeting ... See more keywords