Alternative Approaches to Understand Microtubule Cap Morphology and Function
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06926
Abstract: Microtubules (MTs) are essential cellular machines built from concatenated αβ-tubulin heterodimers. They are responsible for two central and opposite functions from the dynamic point of view: scaffolding (static filaments) and force generation (dynamic MTs). These… read more here.
Keywords: understand microtubule; cap; gtp; alternative approaches ... See more keywords
Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210554
Abstract: Hypoxia is a common denominator in the pathophysiology of a variety of human disease states. Insight into how cells detect, and respond to low oxygen is crucial to understanding the role of hypoxia in disease.… read more here.
Keywords: understand oxygen; advances understanding; oxygen sensing; approaches understand ... See more keywords
Phenomics approaches to understand genetic networks and gene function in yeast
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210285
Abstract: Over the past decade, major efforts have been made to systematically survey the characteristics or phenotypes associated with genetic variation in a variety of model systems. These so-called phenomics projects involve the measurement of ‘phenomes’,… read more here.
Keywords: genetic networks; approaches understand; phenomics approaches; gene function ... See more keywords
Single-cell approaches to understand genome organisation throughout the cell cycle.
Sign Up to like & getrecommendations! Published in 2019 at "Essays in biochemistry"
DOI: 10.1042/ebc20180043
Abstract: Mammalian genomes are ordered at several scales, ranging from nucleosomes (beads on a string), to topologically associated domains (TADs), laminar associated domains (LADs), and chromosome territories. These are described briefly below and we refer the… read more here.
Keywords: cell approaches; approaches understand; cell; single cell ... See more keywords
Systems biology approaches to understand the effects of nutrition and promote health.
Sign Up to like & getrecommendations! Published in 2017 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.12965
Abstract: Within the last years the implementation of systems biology in nutritional research has emerged as a powerful tool to understand the mechanisms by which dietary components promote health and prevent disease as well as to… read more here.
Keywords: biology approaches; approaches understand; promote health; biology ... See more keywords
Imaging approaches to understand disease complexity: chronic obstructive pulmonary disease as a clinical model.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00143.2017
Abstract: The clinical manifestations of chronic obstructive pulmonary disease (COPD) reflect an aggregate of multiple pulmonary and extrapulmonary processes. It is increasingly clear that full assessment of these processes is essential to characterize disease burden and… read more here.
Keywords: chronic obstructive; approaches understand; imaging approaches; obstructive pulmonary ... See more keywords
Cockayne Syndrome: The many challenges and approaches to understand a multifaceted disease
Sign Up to like & getrecommendations! Published in 2020 at "Genetics and Molecular Biology"
DOI: 10.1590/1678-4685-gmb-2019-0085
Abstract: Abstract The striking and complex phenotype of Cockayne syndrome (CS) patients combines progeria-like features with developmental deficits. Since the establishment of the in vitro culture of skin fibroblasts derived from patients with CS in the… read more here.
Keywords: cockayne syndrome; challenges approaches; many challenges; syndrome many ... See more keywords
What Can We Learn from -Omics Approaches to Understand Clubroot Disease?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116293
Abstract: Clubroot is one of the most economically significant diseases worldwide. As a result, many investigations focus on both curing the disease and in-depth molecular studies. Although the first transcriptome dataset for the clubroot disease describing… read more here.
Keywords: clubroot disease; learn omics; disease; omics approaches ... See more keywords