Repurposing approved drugs on the pathway to novel therapies
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21627
Abstract: The time and cost of developing new drugs have led many groups to limit their search for therapeutics to compounds that have previously been approved for human use. Many “repurposed” drugs, such as derivatives of… read more here.
Keywords: pathway novel; drugs pathway; approved drugs; repurposing approved ... See more keywords
Repurposing Drugs Based on Evolutionary Relationships Between Targets of Approved Drugs and Proteins of Interest.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8955-3_3
Abstract: Drug repurposing has garnered much interest as an effective method for drug development among biopharmaceutical companies. The availability of information on complete sequences of genomes and their associated biological data, genotype-phenotype-disease relationships, and properties of… read more here.
Keywords: repurposing drugs; evolutionary relationships; drugs proteins; approved drugs ... See more keywords
Screening and Identification of Marburg Virus Entry Inhibitors Using Approved Drugs
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00184-3
Abstract: Marburg virus (MARV) belongs to the Filoviridae family, along with the related Ebola virus (EBOV). Although MARV is less renowned than EBOV, it causes an equally devastating disease, with clinical symptoms similar to EBOV infection… read more here.
Keywords: marburg virus; marv; approved drugs; screen ... See more keywords
Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptor
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.100982
Abstract: Respiratory transmission is the primary route of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Angiotensin I converting enzyme 2 (ACE2) is the known receptor of SARS-CoV-2 surface spike glycoprotein for entry into human cells.… read more here.
Keywords: interact; ace2; approved drugs; ace1 ... See more keywords
Identification of FDA approved drugs and nucleoside analogues as potential SARS-CoV-2 A1pp domain inhibitor: An in silico study
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2020.104185
Abstract: Coronaviruses are known to infect respiratory tract and intestine. These viruses possess highly conserved viral macro domain A1pp having adenosine diphosphate (ADP)-ribose binding and phosphatase activity sites. A1pp inhibits adenosine diphosphate (ADP)-ribosylation in the host… read more here.
Keywords: cov a1pp; approved drugs; a1pp domain; drugs nucleoside ... See more keywords
Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.10.019
Abstract: Background The pharmacological activation of thermogenesis in brown adipose tissue has long been considered promising strategies to treat obesity. However, identification of safe and effective agents remains a challenge. In this study, we addressed this… read more here.
Keywords: ucp1 expression; approved drugs; obesity; fda approved ... See more keywords
Pharmacogenetic Labeling of FDA-Approved Drugs
Sign Up to like & getrecommendations! Published in 2018 at "JACC: Basic to Translational Science"
DOI: 10.1016/j.jacbts.2018.06.001
Abstract: Summary The U.S. Food and Drug Administration recently marked 10 years since first updating the labeling for warfarin (often referred to as the “poster child” of pharmacogenomics) to include information regarding the potential impact of… read more here.
Keywords: pharmacogenetic labeling; medicine; labeling fda; approved drugs ... See more keywords
Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease
Sign Up to like & getrecommendations! Published in 2020 at "Life Sciences"
DOI: 10.1016/j.lfs.2020.117627
Abstract: Abstract Aims In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of… read more here.
Keywords: virtual screening; fda approved; main protease; approved drugs ... See more keywords
Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2020.104960
Abstract: Abstract Coronavirus Disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a crude case fatality rate of about 0.5-10% depending on locality. A few clinically approved drugs,… read more here.
Keywords: approved drugs; covid; two tier; screening system ... See more keywords
Half-Sandwich Ruthenium Arene Complexes Bearing Clinically Approved Drugs as Ligands: The Importance of Metal-Drug Synergism in Metallodrug Design.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c01027
Abstract: A novel strategy in metallodrug discovery today is incorporating clinically approved drugs into metal complexes as coordinating ligands. Using this strategy, various drugs have been repurposed to prepare organometallic complexes to overcome the resistance of… read more here.
Keywords: clinically approved; approved drugs; drug synergism; half sandwich ... See more keywords
Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10133-y
Abstract: Repurposing FDA-approved drugs is an efficient and cost-effective approach in the development of therapeutics for a broad range of diseases. However, prediction of function can be challenging, especially in the brain. We screened a small-molecule… read more here.
Keywords: fda approved; cluster analysis; approved drugs; behavioral profiles ... See more keywords