High voriconazole target‐site exposure after approved sequence dosing due to nonlinear pharmacokinetics assessed by long‐term microdialysis
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DOI: 10.1016/j.ejps.2019.02.001
Abstract: &NA; Voriconazole, a broad‐spectrum antifungal drug used to prevent and treat invasive fungal infections, shows complex pharmacokinetics and is primarily metabolised by various CYP enzymes. An adequate unbound antibiotic concentration‐time profile at the target‐site of… read more here.
Keywords: sequence dosing; microdialysis; approved sequence; target site ... See more keywords