Maternal separation exacerbates Alzheimer’s disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.10.030
Abstract: &NA; Alzheimer's disease (AD), the most common neurodegenerative disorder that gradually destroys memory and cognitive abilities in the elderly, makes a huge emotional and economic burden on the patients and their families. The presence of… read more here.
Keywords: ps1de9 mice; appswe ps1de9; maternal separation;
Depressive- and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.07.007
Abstract: HIGHLIGHTSDepressive‐like and anxiety‐like symptoms in 16‐week‐old APP/PS1 mice.APP/PS1 mice showed low levels of serum corticosterone.Chronic mild stress aggravated anxiety‐like behaviors, but not depressive‐like behaviors of APP/PS1 mice.CMS caused more severe neuroinflammation of APP/PS1 mice. ABSTRACT… read more here.
Keywords: anxiety like; chronic mild; appswe ps1de9; mice ... See more keywords
Amelioration of cognitive impairments in APPswe/PS1dE9 mice is associated with metabolites alteration induced by total salvianolic acid
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DOI: 10.1371/journal.pone.0174763
Abstract: Purpose Total salvianolic acid (TSA) is extracted from salvia miltiorrhiza; however, to date, there has been limited characterization of its effects on metabolites in Alzheimer’s disease model-APPswe/PS1dE9 mice. The main objective of this study was… read more here.
Keywords: ps1de9 mice; salvianolic acid; learning memory; mice ... See more keywords
Longitudinal assessment of cognitive function in the APPswe/PS1dE9 mouse model of Alzheimer’s-related beta-amyloidosis
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DOI: 10.2139/ssrn.4330042
Abstract: Preclinical models of Alzheimer's disease (AD)-related cognitive decline can be useful for developing therapeutics. The current study longitudinally assessed short-term memory, using a delayed matching-to-position (DMTP) task, and attention, using a 3-choice serial reaction time… read more here.
Keywords: amyloidosis; appswe ps1de9; mouse model; mice ... See more keywords
Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.958876
Abstract: Neuronal hyperexcitability in Alzheimer’s disease (AD) models is thought to either contribute to the formation of amyloid beta plaques or result from their formation. Neuronal hyperexcitability has been shown in the cerebral cortex of the… read more here.
Keywords: alzheimer disease; appswe ps1de9; excitability spontaneous; spontaneous postsynaptic ... See more keywords