Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor
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DOI: 10.1016/j.bbr.2017.11.010
Abstract: HIGHLIGHTSActivation of the sigma‐1 receptor, an ER chaperone, is neuroprotective in Alzheimer's disease.Invalidation of the sigma‐1 receptor facilitated A&bgr;25–35 peptide learning deficit and toxicity in mice.APPSweInd/S1RKO mice presented, at 8 months of age, a more… read more here.
Keywords: appsweind s1rko; toxicity; mice; sigma receptor ... See more keywords