Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment.
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DOI: 10.1021/acs.orglett.2c02482
Abstract: Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation. By combining different redox-economical… read more here.
Keywords: apratoxin; fragment; synthesis; polyketide fragment ... See more keywords