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   Articles with "apremilast" as a keyword



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Real-world registry-based study on apremilast use in psoriasis and psoriatic arthritis in Finland.

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recommendations! Published in 2023 at "Scandinavian journal of rheumatology"

DOI: 10.1080/03009742.2022.2151109

Abstract: OBJECTIVES This study assessed the position of apremilast in the treatment pathway of psoriasis (PsO) and psoriatic arthritis (PsA) in Finnish clinical practice, compared the characteristics of apremilast and biologic therapy users, evaluated persistence with… read more here.

Keywords: persistence; pso psa; apremilast; psoriatic arthritis ... See more keywords
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Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis.

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recommendations! Published in 2019 at "Rheumatology"

DOI: 10.1093/rheumatology/kez204

Abstract: OBJECTIVES Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL-10 (B10 cells), a critical anti-inflammatory B-cell subset, were found to be decreased in both… read more here.

Keywords: breg cells; psoriatic arthritis; apremilast; psa psoriasis ... See more keywords
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Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance

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recommendations! Published in 2018 at "Alcoholism: Clinical and Experimental Research"

DOI: 10.1111/acer.13615

Abstract: BACKGROUND In our companion paper, we reported that the phosphodiesterase type 4 inhibitor apremilast reduced ethanol (EtOH) intake and preference in different drinking models in male and female C57BL/6J mice. In this study, we measured… read more here.

Keywords: apremilast; etoh induced; etoh; functional tolerance ... See more keywords
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Evolving utility of apremilast in dermatological disorders for off‐label indications

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recommendations! Published in 2022 at "Clinical and Experimental Dermatology"

DOI: 10.1111/ced.15377

Abstract: Apremilast, a small molecule that acts by inhibition of the phosphodiesterase‐4 enzyme, has been approved by the US Food and Drug Administration for the management of psoriatic arthritis, plaque psoriasis and Behçet disease. The drug… read more here.

Keywords: label indications; apremilast; utility apremilast; dermatology ... See more keywords
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Successful use of apremilast as a steroid‐sparing agent in chronic actinic dermatitis

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recommendations! Published in 2020 at "Dermatologic Therapy"

DOI: 10.1111/dth.13809

Abstract: Dear Editor, Chronic actinic dermatitis (CAD) is an immune-mediated photosensitive skin disease, characterized by persistent eczematous skin lesions, predominantly affecting sun-exposed areas. Severe, refractory disease entails use of systemic immunosuppressants like corticosteroids. Apremilast is a… read more here.

Keywords: actinic dermatitis; apremilast; chronic actinic; successful use ... See more keywords
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AB0844 SERUM sCD40L LEVEL CAN PREDICT SHORT-TERM CLINICAL OUTCOMES IN PATIENTS WITH PSORIATIC ARTHRITIS ON TREATMENT WITH APREMILAST.

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recommendations! Published in 2020 at "Annals of the Rheumatic Diseases"

DOI: 10.1136/annrheumdis-2020-eular.4644

Abstract: The pathogenesis of Psoriatic Arthritis (PsA) involves several pathways simultaneously, including the CD40/CD40L interaction. In vitro evidence suggests that the cleavage of soluble CD40L (sCD40L) may happen as a Phosphodiesterase 4- (PDE4) dependent reaction [1-3].Here… read more here.

Keywords: apremilast; none; none declared; treatment ... See more keywords
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Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats

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recommendations! Published in 2019 at "International Journal of Nanomedicine"

DOI: 10.2147/ijn.s195048

Abstract: Background Apremilast (APM) is a novel, orally administered small molecule drug approved for treatment of psoriasis or psoriatic arthritis. Due to its low solubility and permeability, it is classified as a class IV drug according… read more here.

Keywords: apremilast; vivo pharmacokinetic; plga nanoparticles; sustained release ... See more keywords
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Biologic initiation rates in systemic-naive psoriasis patients after first-line apremilast versus methotrexate use.

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recommendations! Published in 2022 at "Journal of comparative effectiveness research"

DOI: 10.2217/cer-2021-0311

Abstract: Aim: To compare rates of biologic initiation after commencing treatment with apremilast (APR) versus methotrexate (MTX) in systemic-naive patients with psoriasis (PsO). Methods: This was a retrospective cohort study of systemic-naive patients with PsO who… read more here.

Keywords: versus methotrexate; apremilast; biologic initiation; systemic naive ... See more keywords
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Interleukin-19 Levels Are Increased in Palmoplantar Pustulosis and Reduced following Apremilast Treatment

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24021276

Abstract: Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease characterised by neutrophilic granulocyte (neutrophil)-filled pustules on the palms and soles. The pathogenesis of PPP is poorly understood. This study conducted an identification of the immune… read more here.

Keywords: apremilast; ppp; blood; treatment ... See more keywords
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Apremilast Improves Endothelial Glycocalyx Integrity, Vascular and Left Ventricular Myocardial Function in Psoriasis

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recommendations! Published in 2022 at "Pharmaceuticals"

DOI: 10.3390/ph15020172

Abstract: The phosphodiesterase 4 inhibitor apremilast is used for the treatment of psoriasis. We investigated the effects of apremilast on endothelial glycocalyx, vascular and left ventricular (LV) myocardial function in psoriasis. One hundred and fifty psoriatic… read more here.

Keywords: apremilast; myocardial function; glycocalyx integrity; etanercept cyclosporine ... See more keywords
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Real-world biologic and apremilast treatment patterns and healthcare costs in moderate-to-severe plaque psoriasis.

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recommendations! Published in 2021 at "Dermatology online journal"

DOI: 10.5070/d3271052018

Abstract: Plaque psoriasis is a chronic disease requiring long-term therapy. However, long-term real-world treatment patterns and costs are not well characterized. This study examined treatment patterns and healthcare costs among patients newly initiating a biologic or… read more here.

Keywords: apremilast; plaque psoriasis; treatment; psoriasis ... See more keywords