Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome.
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DOI: 10.1016/j.kint.2017.07.023
Abstract: Volume retention in nephrotic syndrome has been linked to activation of the epithelial sodium channel (ENaC) by proteolysis of its γ-subunit following urinary excretion of serine proteases such as plasmin. Here we tested whether pharmacological… read more here.
Keywords: aprotinin; volume retention; activation; retention ... See more keywords
APROTININ USE IN CARDIAC SURGERY IN A TERTIARY CENTRE IN IRELAND: CASE NUMBERS, INDICATIONS & COMPARISON TO TRANEXAMIC ACID
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DOI: 10.1053/j.jvca.2021.08.075
Abstract: Introduction Aprotinin is a serine protease inhibitor which is used in cardiac surgery as an anti-fibrinolytic agent to minimise patient bleeding. It was withdrawn from the European market in 2008 due to potential increased mortality… read more here.
Keywords: tertiary centre; cardiac surgery; surgery; aprotinin ... See more keywords