In a mouse model of INCL reduced S‐palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12379
Abstract: S‐palmitoylation is a reversible posttranslational modification in which a 16‐carbon saturated fatty acid (generally palmitate) is attached to specific cysteine residues in polypeptides via thioester linkage. Dynamic S‐palmitoylation (palmitoylation‐depalmitoylation), like phosphorylation‐dephosphorylation, regulates the function of… read more here.
Keywords: palmitoylation; incl; apt1; proliferation ... See more keywords