Aptamer and N-Degron Ensemble (AptaGron) as a Target Protein Degradation Strategy
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DOI: 10.1021/acschembio.4c00536
Abstract: Target protein degradation (TPD) is a promising strategy for catalytic downregulation of target proteins through various cellular proteolytic pathways. Despite numerous reports on novel TPD mechanisms, the discovery of target-specific ligands remains a major challenge.… read more here.
Keywords: aptagron; protein degradation; target protein; target ... See more keywords