Characterisation of an aptamer against the Runt domain of AML1 (RUNX1) by NMR and mutational analyses
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12368
Abstract: Since the invention of systematic evolution of ligands by exponential enrichment, many short oligonucleotides (or aptamers) have been reported that can bind to a wide range of target molecules with high affinity and specificity. Previously,… read more here.
Keywords: high affinity; domain aml1; runt domain; aptamer ... See more keywords
Tumor‐Specific Aptamer‐Conjugated Polymeric Photosensitizer for Effective Endo‐Laparoscopic Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201900084
Abstract: Recent advances in medical technology and endo‐laparoscopic devices have enabled the treatment of gastrointestinal (GI) cancers to be minimally invasive through endo‐laparoscopic photodynamic therapy (PDT). To achieve an efficient regional or endo‐laparoscopic PDT, it is… read more here.
Keywords: endo laparoscopic; tumor; laparoscopic; laparoscopic photodynamic ... See more keywords
A non-G-Quadruplex DNA Aptamer Targeting NCL for Diagnosis and Therapy in Bladder Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300791
Abstract: Bladder cancer (BC) is a highly aggressive malignant tumor affecting the urinary system, characterized by metastasis and a poor prognosis that often leads to limited therapeutic success. In this study, we aimed to develop a… read more here.
Keywords: dna aptamer; non quadruplex; bladder cancer; cancer ... See more keywords
Development of a Novel DNA Aptamer Targeting Colorectal Cancer Cell-Derived Small Extracellular Vesicles as a Potential Diagnostic and Therapeutic Agent.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300854
Abstract: Colorectal cancer (CRC) as the second leading cause of global cancer deaths poses critical challenges in clinical settings. Cancer-derived small extracellular vesicles (sEVs), which are secreted by cancer cells, have been shown to mediate tumor… read more here.
Keywords: cell; development; diagnostic therapeutic; cancer ... See more keywords
DNAzyme–aptamer or aptamer–DNAzyme paradigm: Biochemical approach for aflatoxin analysis
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1563
Abstract: DNAzyme and aptamer conjugations have already been used for sensitive and accurate detection of several molecules. In this study, we tested the relationship between conjugation orientation of DNAzyme and aflatoxin B1 aptamer and their subsequent… read more here.
Keywords: dnazyme; analysis; aptamer dnazyme; dnazyme aptamer ... See more keywords
Cardiovascular biomarker troponin I biosensor: Aptamer‐gold‐antibody hybrid on a metal oxide surface
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2380
Abstract: Myocardial infarction (MI) is highly related to cardiac arrest leading to death and organ damage. Radiological techniques and electrocardiography have been used as preliminary tests to diagnose MI; however, these techniques are not sensitive enough… read more here.
Keywords: biomarker; surface; gold; troponin ... See more keywords
Isolation of a novel DNA aptamer against LipL32 as a potential diagnostic agent for the detection of pathogenic Leptospira
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200418
Abstract: Leptospirosis is a potentially life‐threatening zoonosis caused by pathogenic Leptospira and for rapid diagnostics, direct detection is desirable. LipL32 protein is the most suitable biomarker for direct detection. DNA aptamers are sought to be generated… read more here.
Keywords: dna aptamer; pathogenic leptospira; detection; aptamer ... See more keywords
Anti‐epithelial cell adhesion molecule RNA aptamer‐conjugated liposomal doxorubicin as an efficient targeted therapy in mice bearing colon carcinoma tumor model
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Progress"
DOI: 10.1002/btpr.3116
Abstract: To overcome the lack of selectivity and nonspecific biodistribution of drugs in the body, targeted delivery of chemotherapeutic agents with aptamers is a very effective method. In this strategy, aptamers could be specifically identified and… read more here.
Keywords: epithelial cell; anti epithelial; cell adhesion; cell ... See more keywords
A cross‐linked anti‐TNF‐α aptamer for neutralization of TNF‐α‐induced cutaneous Shwartzman phenomenon: A simple and novel approach for improving aptamers' affinity and efficiency
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Progress"
DOI: 10.1002/btpr.3191
Abstract: To increase the efficiency of aptamers to their targets, a simple and novel method has been developed based on aptamer oligomerization. To this purpose, previously anti‐human TNF‐α aptamer named T1–T4 was trimerized through a trimethyl… read more here.
Keywords: tnf; aptamer; cutaneous shwartzman; anti tnf ... See more keywords
7,8‐Dihydro‐8‐oxoguanosine Lesions Inhibit the Theophylline Aptamer or Change Its Selectivity
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.201900684
Abstract: Aptamers are attractive constructs due to their high affinity/selectivity towards a target. Here 7,8‐dihydro‐8‐oxoguanosine (8‐oxoG) has been used, due in part to its unique H‐bonding capabilities (Watson–Crick or Hoogsteen), to expand the “RNA alphabet”. Its… read more here.
Keywords: change; lesions inhibit; dihydro oxoguanosine; oxoguanosine lesions ... See more keywords
2‐Aminopurine Fluorescence Spectroscopy for Probing a Glucose Binding Aptamer
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200127
Abstract: Glucose is the most important analyte for biosensors. Recently a DNA aptamer was reported allowing binding‐based detection. However, due to a relatively weak binding affinity, it is difficult to perform binding assays to understand the… read more here.
Keywords: spectroscopy; aminopurine; fluorescence spectroscopy; fluorescence ... See more keywords