Conjugating aptamer and mitomycin C with reductant-responsive linker leading to synergistically enhanced anti-cancer effect.
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DOI: 10.1021/jacs.9b12409
Abstract: Mitomycin C (MMC) has been using for the treatment of a variety of digestive tract cancers. However, its nonspecific DNA-alkylating ability usually causes severe side effects, thus largely limiting its clinical applications. The utilization of… read more here.
Keywords: effect; linker; aptamer mitomycin; mitomycin ... See more keywords