Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00864-2
Abstract: IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its… read more here.
Keywords: inhibits signaling; aptamer specifically; structure; dna aptamer ... See more keywords
Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1293
Abstract: Abstract The HIV-1 capsid core participates in several replication processes. The mature capsid core is a lattice composed of capsid (CA) monomers thought to assemble first into CA dimers, then into ∼250 CA hexamers and… read more here.
Keywords: hiv capsid; aptamer specifically; replication; lattice ... See more keywords