Mathematical Approaches in Estimating Aptamer Target Binding Affinity.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113742
Abstract: The performance of aptamers as versatile biomolecular tools in numerous analytical applications is critically dependent on their high target binding specificity and selectivity. However, only the technical or methodological aspects of measuring aptamer-target binding affinities… read more here.
Keywords: aptamer target; target; binding affinity; mathematical models ... See more keywords
Aptamer-Target Recognition-Promoted Ratiometric Electrochemical Strategy for Evaluating the Microcystin-LR Residue in Fish without Interferences.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c06476
Abstract: Given the significance of food safety, it is highly urgent to develop a sensitive yet reliable sensor for the practical analysis of algal toxins. As most of the developed sensors are disturbed by interfering substances… read more here.
Keywords: ratiometric electrochemical; recognition; ssdna; aptamer target ... See more keywords
Prediction of Aptamer Protein Interaction using Random Forest Algorithm
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Access"
DOI: 10.1109/access.2022.3172278
Abstract: Aptamers are oligonucleotides that may attach to amino acids, polypeptide, tiny compounds, allergens and living cell membrane. Therapeutics, bio sensing and diagnostics are all sectors where the aptamers may be used. In this work, we… read more here.
Keywords: aptamer protein; interaction; aptamer target; random forest ... See more keywords
Successes and Failures of Static Aptamer-Target 3D Docking Models
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DOI: 10.3390/ijms232214410
Abstract: While Molecular Dynamics simulation programs are probably superior for predicting the binding and affinity of aptamers and their cognate ligands, such molecular dynamics programs require more computing power and analysis time than static docking programs… read more here.
Keywords: static aptamer; aptamer target; successes failures; failures static ... See more keywords