Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives
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DOI: 10.1093/nar/gkaa1109
Abstract: Abstract The thrombin binding aptamer (TBA) possesses promising antiproliferative properties. However, its development as an anticancer agent is drastically impaired by its concomitant anticoagulant activity. Therefore, suitable chemical modifications in the TBA sequence would be… read more here.
Keywords: aptamer tba; tba; tba derivatives; binding aptamer ... See more keywords