Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein
Sign Up to like & getrecommendations! Published in 2020 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.0c01394
Abstract: The World Health Organization has declared the outbreak of a novel coronavirus (SARS-CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the coronavirus infection are not yet fully understood, nor are there any… read more here.
Keywords: discovery aptamers; binding domain; sars cov; aptamers targeting ... See more keywords
Isolation, characterization and testing of RNA aptamers targeting glutamate receptors in a rat spinal cord injury pain model
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08772-8
Abstract: Spinal cord injury (SCI)-induced neuropathic pain remains difficult to treat. Given the high risk of using opioid analgesics as a primary treatment option, developing non-opioid therapeutic candidates is desirable. Studies in preclinical pain models have… read more here.
Keywords: glutamate receptors; spinal cord; pain; aptamers targeting ... See more keywords
DNA aptamers targeting P. aeruginosa RNAP.
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DOI: 10.1039/d5cc00682a
Abstract: We present the first DNA aptamers designed to target the RNA polymerase (RNAP) of Pseudomonas aeruginosa. Utilizing SELEX, we identified and examined aptamers, among which the R2 aptamer demonstrated high specificity and significant binding affinity… read more here.
Keywords: aptamers targeting; rnap; dna aptamers; aeruginosa rnap ... See more keywords