XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity.
Sign Up to like & getrecommendations! Published in 2018 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.02.004
Abstract: Aprataxin (APTX) is a DNA-adenylate hydrolase that removes 5'-AMP blocking groups from abortive ligation repair intermediates. XRCC1, a multi-domain protein without catalytic activity, interacts with a number of known repair proteins including APTX, modulating and… read more here.
Keywords: dna; xrcc1 phosphorylation; activity; xrcc1 ... See more keywords
APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrad007
Abstract: Abstract Aprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA… read more here.
Keywords: aptx; xrcc4; strand break; break repair ... See more keywords