Articles with "apyrimidinic endonuclease" as a keyword



Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin

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Published in 2017 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.22495

Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein crucial for repair of oxidized DNA damage not only in genomic DNA but also in mitochondrial DNA. Parkin, a tumor suppressor and Parkinson's disease (PD) associated gene,… read more here.

Keywords: polyubiquitination; ape1; apurinic apyrimidinic; parkin ... See more keywords
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Graphene Oxide-Assisted and DNA-Modulated SERS of AuCu Alloy for the Fabrication of Apurinic/Apyrimidinic Endonuclease 1 Biosensor.

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Published in 2019 at "Small"

DOI: 10.1002/smll.201901506

Abstract: Fabrication of high-performance surface-enhanced Raman scattering (SERS) biosensors relies on the coordination of SERS substrates and sensing strategies. Herein, a SERS active AuCu alloy with a starfish-like structure is prepared using a surfactant-free method. By… read more here.

Keywords: graphene oxide; aucu alloy; biosensor; fabrication ... See more keywords
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Protein-Scaffolded DNA Nanostructures for Imaging of Apurinic/Apyrimidinic Endonuclease 1 Activity in Live Cells.

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Published in 2023 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.2c05504

Abstract: Nucleic acids are valuable tools for intracellular biomarker detection and gene regulation. Here we propose a new type of protein (avidin)-scaffolded DNA nanostructure (ADN) for imaging the activity of apurinic/apyrimidinic endonuclease 1 (APE1) in live… read more here.

Keywords: apyrimidinic endonuclease; live cells; activity; scaffolded dna ... See more keywords
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Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.

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Published in 2019 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.8b01529

Abstract: Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified… read more here.

Keywords: endonuclease; inhibition ape1; apurinic apyrimidinic; macrocyclic inhibitors ... See more keywords
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Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells.

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Published in 2019 at "Nanoscale"

DOI: 10.1039/c9nr06436b

Abstract: A highly sensitive enzyme-free amplification assay for the detection of apurinic/apyrimidinic endonuclease 1 activity was developed. By incorporating biodegradable MnO2 nanosheets, in situ light up intracellular APE 1 activity was achieved. read more here.

Keywords: endonuclease activity; biodegradable mno2; apurinic apyrimidinic; activity ... See more keywords
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Activity of Human Apurinic/Apyrimidinic Endonuclease APE1 Toward Damaged DNA and Native RNA With Non-canonical Structures

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Published in 2020 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2020.590848

Abstract: The primary role of apurinic/apyrimidinic (AP) endonuclease APE1 in human cells is the cleavage of the sugar phosphate backbone 5′ to an AP site in DNA to produce a single-strand break with a 5′-deoxyribose phosphate… read more here.

Keywords: dna native; endonuclease ape1; ape1; apurinic apyrimidinic ... See more keywords
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Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease

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Published in 2022 at "Biomedicines"

DOI: 10.3390/biomedicines10010190

Abstract: Kawasaki disease (KD) refers to systemic vasculitis of medium-sized vessels accompanied by fever. The multifunctional protein apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a new biomarker for vascular inflammation. Here, we investigated the association between APE1/Ref-1 and… read more here.

Keywords: ape1 ref; apurinic apyrimidinic; group; kawasaki disease ... See more keywords
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Visualization and Comparison of the Level of Apurinic/Apyrimidinic Endonuclease 1 in Live Normal/Cancerous and Neuron Cells with a Fluorescent Nanoprobe

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Published in 2023 at "Molecules"

DOI: 10.3390/molecules28093935

Abstract: As a major apurinic/apyrimidinic endonuclease and a redox signaling protein in human cells, APE1 plays a crucial role in cellular function and survival. The relationship between alterations of APE1 expression and subcellular localization and the… read more here.

Keywords: normal cancerous; apyrimidinic endonuclease; fluorescent nanoprobe; live cells ... See more keywords