A Perspective for Ménière’s Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2
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DOI: 10.3390/biom12040511
Abstract: Ménière’s disease is a chronic illness characterized by intermittent episodes of vertigo associated with fluctuating sensorineural hearing loss, tinnitus and aural pressure. This pathology strongly correlates with a dilatation of the fluid compartment of the… read more here.
Keywords: aqp2; water; perspective disease; disease ... See more keywords
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells
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DOI: 10.3390/ijms23020763
Abstract: The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. However, the mechanisms controlling the localization of AQP2 are… read more here.
Keywords: controlling localization; localization; principal cells; inhibitor ... See more keywords
Genome-Engineered mpkCCDc14 Cells as a New Resource for Studying AQP2
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DOI: 10.3390/ijms24021684
Abstract: mpkCCDc14 cells, a polarized epithelial cell line derived from mouse kidney cortical collecting ducts, are known to express the vasopressin V2 receptor (V2R) and aquaporin-2 (AQP2) that are responsive to vasopressin. However, a low abundance… read more here.
Keywords: v2r aqp2; aqp2; genome; ddavp ... See more keywords