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   Articles with "aqp2" as a keyword



Disruption of mitochondrial electron transport impairs urinary concentration via AMPK-dependent suppression of aquaporin 2

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recommendations! Published in 2024 at "JCI Insight"

DOI: 10.1172/jci.insight.182087

Abstract: Urinary concentration is an energy-dependent process that minimizes body water loss by increasing aquaporin 2 (AQP2) expression in collecting duct (CD) principal cells. To investigate the role of mitochondrial (mt) ATP production in renal water… read more here.

Keywords: urinary concentration; electron transport; concentration; aqp2 ... See more keywords

Various endurance training intensities improve GFR and Up-regulate AQP2/GSK3β in lithium-induced nephropathic rats

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recommendations! Published in 2025 at "BMC Nephrology"

DOI: 10.1186/s12882-025-03997-5

Abstract: Lithium is extensively used for mood stabilization in bipolar disorder, but its long-term use can lead to nephrotoxicity, characterized by a reduction in glomerular filtration rate (GFR) and potential progression to end-stage renal disease (ESRD).… read more here.

Keywords: lithium; aqp2; lithium induced; endurance training ... See more keywords

A Perspective for Ménière’s Disease: In Silico Investigations of Dexamethasone as a Direct Modulator of AQP2

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recommendations! Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12040511

Abstract: Ménière’s disease is a chronic illness characterized by intermittent episodes of vertigo associated with fluctuating sensorineural hearing loss, tinnitus and aural pressure. This pathology strongly correlates with a dilatation of the fluid compartment of the… read more here.

Keywords: aqp2; water; perspective disease; disease ... See more keywords

Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23020763

Abstract: The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. However, the mechanisms controlling the localization of AQP2 are… read more here.

Keywords: controlling localization; localization; principal cells; inhibitor ... See more keywords

Genome-Engineered mpkCCDc14 Cells as a New Resource for Studying AQP2

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24021684

Abstract: mpkCCDc14 cells, a polarized epithelial cell line derived from mouse kidney cortical collecting ducts, are known to express the vasopressin V2 receptor (V2R) and aquaporin-2 (AQP2) that are responsive to vasopressin. However, a low abundance… read more here.

Keywords: v2r aqp2; aqp2; genome; ddavp ... See more keywords