AQP4 Aggravates Cognitive Impairment in Sepsis‐Associated Encephalopathy through Inhibiting Nav1.6‐Mediated Astrocyte Autophagy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205862
Abstract: The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects of AQP4 associated with SAE and reveal its underlying mechanism causing cognitive impairment.… read more here.
Keywords: associated encephalopathy; cognitive impairment; sepsis associated; astrocyte ... See more keywords
Post-stroke Impairment of the Blood-Brain Barrier and Perifocal Vasogenic Edema Is Alleviated by Endovascular Mesenchymal Stem Cell Administration: Modulation of the PKCδ/MMP9/AQP4-Mediated Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02761-2
Abstract: Post-stroke edema and upregulation of aquaporin 4 (AQP4) water transport channels play a significant role in the progression of stroke pathology and deteriorating stroke outcomes. Prior studies from our lab have demonstrated the safety and… read more here.
Keywords: post stroke; post; aqp4; brain ... See more keywords
Effective Rituximab Treatment in Patients with Neuromyelitis Optica Spectrum Disorders Compared with Azathioprine and Mycophenolate
Sign Up to like & getrecommendations! Published in 2021 at "Neurology and Therapy"
DOI: 10.1007/s40120-021-00298-5
Abstract: As an autoimmune central nervous system disease characterized by inflammation and demyelination, neuromyelitis optica (NMO) has been extensively investigated. A specific antigenic target, astrocytic water channel aquaporin-4 (AQP4) has already been identified, and it can… read more here.
Keywords: rtx aza; treatment; aqp4; neuromyelitis optica ... See more keywords
Lack of association between unipolar or bipolar depression and serum aquaporin-4 autoantibodies
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.05.001
Abstract: Aquaporin-4 (AQP4), an astrocyte water channel protein, is the target antigen of serum immunoglobulin G (IgG) autoantibody in neuromyelitis optica spectrum disorders (NMOsd), a group of inflammatory, demyelinating diseases of the central nervous system. Recently,… read more here.
Keywords: depression; aqp4; serum; unipolar bipolar ... See more keywords
Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study
Sign Up to like & getrecommendations! Published in 2019 at "Neuroimage"
DOI: 10.1016/j.neuroimage.2018.12.026
Abstract: ABSTRACT There is currently a lack of non‐invasive tools to assess water transport in healthy and pathological brain tissue. Aquaporin‐4 (AQP4) water channels are central to many water transport mechanisms, and emerging evidence also suggests… read more here.
Keywords: water; aqp4; time; non invasive ... See more keywords
Aquaporin-4 deletion attenuates opioid-induced addictive behaviours associated with dopamine levels in nucleus accumbens
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.108986
Abstract: There is a lack of safe and effective non-opioid medications for the treatment of opioid addiction. Aquaporin-4 (AQP4), a water channel protein expressed in astrocytes, regulates the progression of neurological diseases. Our previous work demonstrated… read more here.
Keywords: dopamine; mice; opioid induced; opioid addiction ... See more keywords
Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.07.029
Abstract: Aquaporin-4 (AQP4) is the predominant water channel in mammalian CNS where it is localized at the perivascular astrocytic foot processes abutting brain microvessels. Several lines of evidence suggest that AQP4 is involved in important homeostatic… read more here.
Keywords: mptp; aqp4; aquaporin; substantia nigra ... See more keywords
A highly specific and sensitive nanoimmunosensor for the diagnosis of neuromyelitis optica spectrum disorders
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52506-w
Abstract: A precise diagnosis for neuromyelitis optica spectrum disorders (NMOSD) is crucial to improve patients’ prognostic, which requires highly specific and sensitive tests. The cell-based assay with a sensitivity of 76% and specificity of 100% is… read more here.
Keywords: diagnosis neuromyelitis; spectrum disorders; highly specific; aqp4 ... See more keywords
BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89997-5
Abstract: Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB). Although the molecular mechanisms regulating AQP4… read more here.
Keywords: bmp signaling; cerebral cortex; aqp4; mouse cerebral ... See more keywords
The aquaporin-4 water channel as a potential drug target in neurological disorders
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2017.1398236
Abstract: ABSTRACT Introduction: Aquaporin-4 (AQP4) is a water transporting protein expressed at the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis of AQP4 knockout mice has suggested its broad involvement in brain water… read more here.
Keywords: water; aquaporin water; aqp4; aqp4 inhibitors ... See more keywords
Acutely increased aquaporin-4 exhibits more potent protective effects in the cortex against single and repeated isoflurane-induced neurotoxicity in the developing rat brain
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2022.2127389
Abstract: Abstract Damage to hippocampus, cerebellum, and cortex associated with cognitive functions due to anesthetic-induced toxicity early in life may cause cognitive decline later. Aquaporin 4 (AQP4), a key protein in waste clearance pathway of brain,… read more here.
Keywords: induced neurotoxicity; repeated isoflurane; single repeated; brain ... See more keywords