The aquaporin-4 water channel as a potential drug target in neurological disorders
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2017.1398236
Abstract: ABSTRACT Introduction: Aquaporin-4 (AQP4) is a water transporting protein expressed at the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis of AQP4 knockout mice has suggested its broad involvement in brain water… read more here.
Keywords: water; aquaporin water; aqp4; aqp4 inhibitors ... See more keywords
Toward New AQP4 Inhibitors: ORI-TRN-002
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25020924
Abstract: Cerebral edema is a life-threatening condition that can cause permanent brain damage or death if left untreated. Existing therapies aim at mitigating the associated elevated intracranial pressure, yet they primarily alleviate pressure rather than prevent… read more here.
Keywords: trn 002; edema formation; aqp4 inhibitors; ori trn ... See more keywords