An efficient and rapid synthesis of 3-hydroxy-3-alkyl-2-oxindoles via Zn-mediated barbier-type reaction under aqueous conditions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-017-1329-8
Abstract: Abstract A robust and rapid synthesis of 3-hydroxy-3-alkyl-2-oxindoles from isatins is described. This method introduces an ecofriendly, un-activated Zn dust, solid $$\hbox {NH}_{4}\hbox {Cl}$$NH4Cl and substrates under aqueous conditions, which has produced the product in moderate… read more here.
Keywords: alkyl oxindoles; rapid synthesis; aqueous conditions; synthesis hydroxy ... See more keywords
Rapid Derivatization of Phenolic and Oxime Hydroxyl with Isonicotinoyl Chloride under Aqueous Conditions and Its Application in LC-MS/MS Profiling Multiclass Steroids.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04151
Abstract: Quantification of steroids possesses a crucial clinical value in early diagnosis and prognosis evaluation of various endocrine diseases. However, it is still challenging to realize feasible analysis of estrogens, androgens, progestogens, and corticoids within one… read more here.
Keywords: isonicotinoyl chloride; multiclass steroids; aqueous conditions; derivatization ... See more keywords
o-Nitrobenzyl Oxime Ethers Enable Photoinduced Cyclization Reaction to Provide Phenanthridines under Aqueous Conditions.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04015
Abstract: In this paper, we describe a novel N-O photolysis of o-nitrobenzyl oxime ethers that enables the synthesis of phenanthridines via intramolecular cyclization reactions. Without the use of additional photocatalysts or photosensitizers, the process proceeds with… read more here.
Keywords: reaction; nitrobenzyl oxime; photoinduced cyclization; aqueous conditions ... See more keywords
Molecular Recognition within the Cavity of a Foldamer Helix Bundle: Encapsulation of Primary Alcohols in Aqueous Conditions.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b00181
Abstract: Artificial synthetic molecules able to adopt well-defined stable secondary structures comparable to those found in nature ("foldamers") have considerable potential for use in a range of applications such as biomaterials, biorecognition, nanomachines and as therapeutic… read more here.
Keywords: aqueous conditions; cavity; foldamer helix; helix bundle ... See more keywords
Gold(I)-Mediated Decaging or Cleavage of Propargylated Peptide Bond in Aqueous Conditions for Protein Synthesis and Manipulation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b13216
Abstract: Chemists have been interested in N-alkylation of the peptide bond since such a modification alters the conformation of the amide bond, interferes with hydrogen bond formation and changes other properties of the peptide (e.g. solubility).… read more here.
Keywords: bond; aqueous conditions; peptide bond; protein synthesis ... See more keywords
Revisiting 1-chloro-1,2-benziodoxol-3-one: efficient ortho-chlorination of aryls under aqueous conditions
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj00530c
Abstract: The application of 1-chloro-1,2-benziodoxol-3-one as a powerful chlorinating agent as well as oxidant for aniline derivatives is explored. The amide directing group assisted radical mediated ortho-selective chlorination proceeds in the absence of a radical initiator.… read more here.
Keywords: chlorination; benziodoxol one; chloro benziodoxol; revisiting chloro ... See more keywords
Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc02554e
Abstract: Blending synthetic biology and synthetic chemistry represents a powerful approach to diversity complex molecules. To further enable this, compatible synthetic tools are needed. We report the first Buchwald Hartwig amination reactions with unprotected halotryptophans under… read more here.
Keywords: buchwald hartwig; product barettin; unprotected halotryptophans; aqueous conditions ... See more keywords
Hypophosphite addition to alkenes under solvent-free and non-acidic aqueous conditions.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06831h
Abstract: Hypophosphite adds to alkenes in high yields under solvent-free conditions at elevated temperature, including α,β-unsaturated carboxylates. The reaction proceeds by a radical mediated pathway. Hypophosphite addition is also effective under non-acidic aqueous conditions employing radical… read more here.
Keywords: solvent free; non acidic; acidic aqueous; hypophosphite addition ... See more keywords