Articles with "aqueous solubility" as a keyword



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Captisol®: an efficient carrier and solubilizing agent for essential oils and their components

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Published in 2017 at "Flavour and Fragrance Journal"

DOI: 10.1002/ffj.3395

Abstract: Essential oils (EOs) and their individual components have several biological properties and are used in cosmetics, food and pharmaceutical industries. However, their application still presents a challenge owing mainly to their volatility and their poor… read more here.

Keywords: aqueous solubility; captisol efficient; carrier; solubility ... See more keywords
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Cannabidiol aqueous solubility enhancement: comparison of three amorphous formulations strategies using different type of polymers.

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Published in 2020 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2020.119812

Abstract: Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming and based on… read more here.

Keywords: cbd; aqueous solubility; solubility enhancement; solubility ... See more keywords
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Survey of aqueous solubility, appearance, and pH of plant protein powders from carbohydrate and vegetable oil production

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Published in 2020 at "Lwt - Food Science and Technology"

DOI: 10.1016/j.lwt.2020.110078

Abstract: Abstract There is a need to have functional protein-rich ingredients to formulate a range of vegan and vegetarian products. However, available proteins vary in functionality and in particular in solubility, even if derived from the… read more here.

Keywords: protein powders; plant; aqueous solubility; appearance ... See more keywords
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Bortezomib Aqueous Solubility in the Presence and Absence of D-Mannitol: A Clarification with Formulation Implications.

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Published in 2020 at "Journal of pharmaceutical sciences"

DOI: 10.1016/j.xphs.2020.10.012

Abstract: The solubility of bortezomib, a boronic acid, in water and normal saline is often misquoted in the literature. Here we confirm that bortezomib equilibrium solubility in water and normal saline is 0.59 ± 0.07 and… read more here.

Keywords: presence; mannitol; aqueous solubility; formulation ... See more keywords
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Evaluation of Deep Learning Architectures for Aqueous Solubility Prediction

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Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c00642

Abstract: Determining the aqueous solubility of molecules is a vital step in many pharmaceutical, environmental, and energy storage applications. Despite efforts made over decades, there are still challenges associated with developing a solubility prediction model with… read more here.

Keywords: solubility prediction; solubility; prediction; aqueous solubility ... See more keywords
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Prediction of the Aqueous Solubility of Compounds Based on Light Gradient Boosting Machines with Molecular Fingerprints and the Cuckoo Search Algorithm

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Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c03885

Abstract: Aqueous solubility is one of the most important physicochemical properties in drug discovery. At present, the prediction of aqueous solubility of compounds is still a challenging problem. Machine learning has shown great potential in solubility… read more here.

Keywords: solubility compounds; prediction aqueous; solubility; light gradient ... See more keywords
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Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon

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Published in 2019 at "Communications Chemistry"

DOI: 10.1038/s42004-018-0100-5

Abstract: Peptides and small proteins are attractive therapeutic candidates due to their inherent selectivity and limited off-target effects. Unfortunately, their potential is often hindered by unfavorable physicochemical properties. This is particularly true in the case of… read more here.

Keywords: glucagon; aqueous solubility; therapeutic peptides; stereochemical inversion ... See more keywords
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Estimation of aqueous solubility of starch from various botanical sources using Flory Huggins theory approach

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Published in 2019 at "Chemical Engineering Communications"

DOI: 10.1080/00986445.2019.1691539

Abstract: Abstract The data of aqueous solubility of starch are essential for the determination of appropriate uses of starch and design of starch based food products. Unfortunately, these data are scarce and often, some are inconsistent.… read more here.

Keywords: botanical sources; flory huggins; aqueous solubility; various botanical ... See more keywords
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Enhancement of the aqueous solubility and permeability of a poorly water soluble drug ritonavir via lyophilized milk-based solid dispersions

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Published in 2017 at "Pharmaceutical Development and Technology"

DOI: 10.1080/10837450.2016.1193193

Abstract: Abstract In the present study, a lyophilized milk-based solid dispersion (SD) of ritonavir (RTV) was developed with the goal of improving its aqueous solubility. The SD was prepared by lyophilization, and characterized for its physicochemical… read more here.

Keywords: rtv; aqueous solubility; formulation; lyophilized milk ... See more keywords
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Different molecular enumeration influences in deep learning: an example using aqueous solubility

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Published in 2021 at "Briefings in bioinformatics"

DOI: 10.1093/bib/bbaa092

Abstract: Aqueous solubility is the key property driving many chemical and biological phenomena and impacts experimental and computational attempts to assess those phenomena. Accurate prediction of solubility is essential and challenging, even with modern computational algorithms.… read more here.

Keywords: molecule; different molecular; aqueous solubility; deep learning ... See more keywords
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Spray Dried Xanthone: Physicochemical Properties, Storage Stability and Controlled Release

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Published in 2017 at "Journal of Food Process Engineering"

DOI: 10.1111/jfpe.12407

Abstract: Abstract Xanthone has low aqueous solubility, thus limiting its food application. The aim of this study is to increase aqueous solubility of xanthone through spray drying xanthone in fish oil with maltodextrin and gum Arabic.… read more here.

Keywords: aqueous solubility; spray; spray dried; dried xanthone ... See more keywords