Captisol®: an efficient carrier and solubilizing agent for essential oils and their components
Sign Up to like & getrecommendations! Published in 2017 at "Flavour and Fragrance Journal"
DOI: 10.1002/ffj.3395
Abstract: Essential oils (EOs) and their individual components have several biological properties and are used in cosmetics, food and pharmaceutical industries. However, their application still presents a challenge owing mainly to their volatility and their poor… read more here.
Keywords: aqueous solubility; captisol efficient; carrier; solubility ... See more keywords
Cannabidiol aqueous solubility enhancement: comparison of three amorphous formulations strategies using different type of polymers.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119812
Abstract: Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming and based on… read more here.
Keywords: cbd; aqueous solubility; solubility enhancement; solubility ... See more keywords
Survey of aqueous solubility, appearance, and pH of plant protein powders from carbohydrate and vegetable oil production
Sign Up to like & getrecommendations! Published in 2020 at "Lwt - Food Science and Technology"
DOI: 10.1016/j.lwt.2020.110078
Abstract: Abstract There is a need to have functional protein-rich ingredients to formulate a range of vegan and vegetarian products. However, available proteins vary in functionality and in particular in solubility, even if derived from the… read more here.
Keywords: protein powders; plant; aqueous solubility; appearance ... See more keywords
Bortezomib Aqueous Solubility in the Presence and Absence of D-Mannitol: A Clarification with Formulation Implications.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2020.10.012
Abstract: The solubility of bortezomib, a boronic acid, in water and normal saline is often misquoted in the literature. Here we confirm that bortezomib equilibrium solubility in water and normal saline is 0.59 ± 0.07 and… read more here.
Keywords: presence; mannitol; aqueous solubility; formulation ... See more keywords
Lead Optimization of Positive Allosteric KV7.2/3 Channel Modulators toward Improved Balance of Lipophilicity and Aqueous Solubility.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c03112
Abstract: The voltage-gated potassium channel KV7.2/3 is gaining attention for its association with several medical indications. While recently reported, potent compounds aimed to fill the therapeutic gap left by market-withdrawn activators, key physicochemical parameters did not… read more here.
Keywords: lead optimization; aqueous solubility; channel; lipophilicity ... See more keywords
Novel BODIPY-Based Fluorescent Probes with Improved Aqueous Solubility for Selective Detection of Soluble Aβ Aggregates.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.5c00525
Abstract: Soluble amyloid β (Aβ) aggregates have attracted attention as therapeutic targets and biomarkers of Alzheimer's disease. We previously reported a fluorescent probe, BAOP-16, which targets soluble Aβ aggregates. However, its limited aqueous solubility has hindered… read more here.
Keywords: soluble aggregates; improved aqueous; aqueous solubility; selective detection ... See more keywords
Evaluation of Deep Learning Architectures for Aqueous Solubility Prediction
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00642
Abstract: Determining the aqueous solubility of molecules is a vital step in many pharmaceutical, environmental, and energy storage applications. Despite efforts made over decades, there are still challenges associated with developing a solubility prediction model with… read more here.
Keywords: solubility prediction; solubility; prediction; aqueous solubility ... See more keywords
Prediction of the Aqueous Solubility of Compounds Based on Light Gradient Boosting Machines with Molecular Fingerprints and the Cuckoo Search Algorithm
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03885
Abstract: Aqueous solubility is one of the most important physicochemical properties in drug discovery. At present, the prediction of aqueous solubility of compounds is still a challenging problem. Machine learning has shown great potential in solubility… read more here.
Keywords: solubility compounds; prediction aqueous; solubility; light gradient ... See more keywords
Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon
Sign Up to like & getrecommendations! Published in 2019 at "Communications Chemistry"
DOI: 10.1038/s42004-018-0100-5
Abstract: Peptides and small proteins are attractive therapeutic candidates due to their inherent selectivity and limited off-target effects. Unfortunately, their potential is often hindered by unfavorable physicochemical properties. This is particularly true in the case of… read more here.
Keywords: glucagon; aqueous solubility; therapeutic peptides; stereochemical inversion ... See more keywords
Estimation of aqueous solubility of starch from various botanical sources using Flory Huggins theory approach
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Engineering Communications"
DOI: 10.1080/00986445.2019.1691539
Abstract: Abstract The data of aqueous solubility of starch are essential for the determination of appropriate uses of starch and design of starch based food products. Unfortunately, these data are scarce and often, some are inconsistent.… read more here.
Keywords: botanical sources; flory huggins; aqueous solubility; various botanical ... See more keywords
Enhancement of aqueous solubility of hesperidin and naringenin utilizing hydrotropic solubilization technique: characterization and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2024.2358831
Abstract: Abstract The therapeutic potential of two important flavonoids, i.e. hesperidin and naringenin, remains unutilized due to pharmacokinetics issues, especially poor aqueous solubility. Hydrotropic solid dispersions with different agents like sodium salicylate, niacinamide, benzoic acid, and… read more here.
Keywords: enhancement aqueous; aqueous solubility; hesperidin naringenin; naringenin utilizing ... See more keywords