Targeting AraC-Resistant Acute Myeloid Leukemia by Dual Inhibition of CDK9 and Bcl-2: A Systematic Review and Meta-Analysis
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DOI: 10.1155/2022/2842066
Abstract: Purpose This study aims to determine the influence of targeting araC-resistant acute myeloid leukemia by dual inhibition cyclin-dependent protein kinase (CDK9) and B-cell lymphoma-2 （Bcl-2). Method The c-Myc inhibitor 10058-F4 and the CDK9 inhibitor AZD4573… read more here.
Keywords: myeloid leukemia; resistant acute; cdk9; targeting arac ... See more keywords
Loss of Cystathionine-β-Synthase Activity Results in Increased Oxidative Phosphorylation and Cytarabine Resistance in Myeloid Leukemia Associated with Down Syndrome
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DOI: 10.1182/blood-2024-203961
Abstract: Acute myeloid leukemia (AML) and myelodysplasia in children with Down syndrome (DS) collectively define myeloid leukemia associated with DS (ML-DS) according to the WHO 2016 classification. DS individuals are genetically predisposed to hematologic malignancies, including… read more here.
Keywords: resistance; arac; arac resistant; cell ... See more keywords