Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13221
Abstract: Survival of ovarian carcinoma is associated with the abundance of immunosuppressed CD163high CD206high tumor-associated macrophages (TAMs) and high levels of arachidonic acid (AA) in the tumor microenvironment. Here, we show that both associations are functionally… read more here.
Keywords: raft; lipid raft; microenvironment; acid clinically ... See more keywords
Melamine binding with arachidonic acid binding sites of albumin is a potential mechanism for melamine‐induced inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1512
Abstract: Melamine adulteration of food is a public health concern. It has been seen that melamine causes disease in many organs. Melamine‐induced kidney disease is a well‐recognized clinicopathological entity. Inflammation is thought to be important in… read more here.
Keywords: inflammation; arachidonic acid; acid binding; melamine induced ... See more keywords
Arachidonic acid‐containing phosphatidylcholine characterized by consolidated plasma and liver lipidomics as an early onset marker for tamoxifen‐induced hepatic phospholipidosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3442
Abstract: Lipid profiling has emerged as an effective approach to not only screen disease and drug toxicity biomarkers but also understand their underlying mechanisms of action. Tamoxifen, a widely used antiestrogenic agent for adjuvant therapy against… read more here.
Keywords: plasma liver; tamoxifen induced; liver; arachidonic acid ... See more keywords
Functional characterization of a novel arachidonic acid 12S‐lipoxygenase in the halotolerant bacterium Myxococcus fulvus exhibiting complex social living patterns
Sign Up to like & getrecommendations! Published in 2018 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.775
Abstract: Lipoxygenases are lipid peroxidizing enzymes, which frequently occur in higher plants and mammals. These enzymes are also expressed in lower multicellular organisms but here they are not widely distributed. In bacteria, lipoxygenases rarely occur and… read more here.
Keywords: lipoxygenase; arachidonic acid; functional characterization; myxococcus fulvus ... See more keywords
Ligand‐based Modeling for the Prediction of Pharmacophore Features for Multi‐targeted Inhibition of the Arachidonic Acid Cascade
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Informatics"
DOI: 10.1002/minf.201700073
Abstract: The single‐target drugs against the arachidonic acid inflammatory pathway are associated with serious side effects, hence, as a first step towards multi‐target drugs, we have studied the pharmacophoric features common to the inhibitors of 5‐lipoxygenase‐activating… read more here.
Keywords: ligand based; modeling prediction; based modeling; arachidonic acid ... See more keywords
Arachidonic acid alleviates the detrimental effects of acetylsalicylic acid on human granulosa cells performance in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23343
Abstract: Here, we investigated the biological effects of arachidonic acid (AA) in human cumulus granulosa cells (CGCs) after exposure to ASA. Cells were isolated from the follicular fluid and incubated with 0.5 mM acetylsalicylic acid (ASA) and… read more here.
Keywords: granulosa cells; acid human; acetylsalicylic acid; arachidonic acid ... See more keywords
The aflatoxin B1‐fumonisin B1 toxicity in BRL‐3A hepatocytes is associated to induction of cytochrome P450 activity and arachidonic acid metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22395
Abstract: Human oral exposure to aflatoxin B1 (AFB1) and fumonisin B1 (FB1) is associated with increased hepatocellular carcinoma. Although evidence suggested interactive AFB1–FB1 hepatotoxicity, the underlying mechanisms remain mostly unidentified. This work was aimed at evaluating… read more here.
Keywords: afb1; metabolism; afb1 fb1; arachidonic acid ... See more keywords
Arachidonic Acid and Nitroarachidonic: Effects on NADPH Oxidase Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-11488-6_6
Abstract: Arachidonic acid (AA) is a polyunsaturated fatty acid that participates in the inflammatory response mainly through bioactive-lipids formation in macrophages and also in the phagocytic NADPH oxidase 2 (NOX2) activation. NOX2 is the enzyme responsible… read more here.
Keywords: formation; arachidonic acid; nadph oxidase; acid ... See more keywords
11-Hydroperoxide eicosanoid-mediated 2(E),4(E)-decadienal production from arachidonic acid in the brown algae, Saccharina angustata
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-019-01776-y
Abstract: This work aims to propose a pathway for the production of 2(E),4(E)-decadienal from arachidonic acid (ARA) via 11-hydroperoxide eicosanoid (11 hydroperoxyeicosatetraenoic acid, 11-HPETE) through lipoxygenase (LOX) and hydroperoxide lyase (HPL) in the brown alga, Saccharina… read more here.
Keywords: production; ara; arachidonic acid; pathway ... See more keywords
Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti, bound to arachidonic acid
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecular Nmr Assignments"
DOI: 10.1007/s12104-019-09875-0
Abstract: Aedes aegypti mosquitoes are the vector for transmission of Dengue, Zika and chikungunya viruses. These mosquitos feed exclusively on human hosts for a blood meal. Previous studies have established that Dengue virus infection of the… read more here.
Keywords: aedes aegypti; chemical shift; arachidonic acid; shift assignments ... See more keywords
Arachidonic acid effects on the overall performance, fatty acid profile, hepatopancreas morphology and lipid-relevant genes in Litopenaeus vannamei juveniles
Sign Up to like & getrecommendations! Published in 2020 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2020.735207
Abstract: Abstract The effect of arachidonic acid (ARA) was evaluated on Litopenaeus vannamei juveniles. Growth performance; hepatopancreas and muscle fatty acid compositions; hepatopancreatic cells morphology; and expression of lipid-relevant genes were estimated after six-week experiment. A… read more here.
Keywords: litopenaeus vannamei; vannamei juveniles; fatty acid; arachidonic acid ... See more keywords