Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro.
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DOI: 10.1194/jlr.ra120000682
Abstract: Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors… read more here.
Keywords: characterization small; vitro; acid sphingomyelinase; arc39 ... See more keywords