Bayesian reassessment of the epigenetic architecture of complex traits
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16520-1
Abstract: Linking epigenetic marks to clinical outcomes improves insight into molecular processes, disease prediction, and therapeutic target identification. Here, a statistical approach is presented to infer the epigenetic architecture of complex disease, determine the variation captured… read more here.
Keywords: variation captured; bayesian reassessment; epigenetic architecture; architecture complex ... See more keywords
Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS computational biology"
DOI: 10.1371/journal.pcbi.1009483
Abstract: The number of variants that have a non-zero effect on a trait (i.e. polygenicity) is a fundamental parameter in the study of the genetic architecture of a complex trait. Although many previous studies have investigated… read more here.
Keywords: causal snps; architecture complex; regional polygenicity; genetic architecture ... See more keywords