Defining the architecture of the human TIM22 complex by chemical crosslinking
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13978
Abstract: The majority of mitochondrial proteins are nuclear encoded and imported into mitochondria as precursor proteins via dedicated translocases. The translocase of the inner membrane 22 (TIM22) is a multisubunit molecular machine specialized for the translocation… read more here.
Keywords: tim22 complex; architecture human; tim22; human tim22 ... See more keywords
Microtubule Attachment and Centromeric Tension Shape the Protein Architecture of the Human Kinetochore
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.09.038
Abstract: The nanoscale protein architecture of the kinetochore plays an integral role in specifying the mechanisms underlying its functions in chromosome segregation. However, defining this architecture in human cells remains challenging because of the large size… read more here.
Keywords: kinetochore; architecture human; microtubule attachment; protein architecture ... See more keywords
Architecture of the human NALCN channelosome
Sign Up to like & getrecommendations! Published in 2022 at "Cell Discovery"
DOI: 10.1038/s41421-022-00392-4
Abstract: NALCN regulates the resting membrane potential by mediating the Na + leak current in neurons, and it functions as a channelosome in complex with FAM155A, UNC79, and UNC80. Dysfunction of the NALCN channelosome causes a… read more here.
Keywords: architecture human; nalcn channelosome; unc79 unc80; unc80 assembly ... See more keywords
Deconstructing and targeting the genomic architecture of human neurodegeneration
Sign Up to like & getrecommendations! Published in 2018 at "Nature Neuroscience"
DOI: 10.1038/s41593-018-0240-z
Abstract: The field of neurodegenerative disease research has seen tremendous advances over the last two decades as new technologies and analytic methods have enabled well-powered human genomic studies. Driven first by genetic studies and more recently… read more here.
Keywords: genomic architecture; targeting genomic; architecture human; disease ... See more keywords