Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice.
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23817
Abstract: Tanycytes are radial glial cells located in the mediobasal hypothalamus. Recent studies have proposed that tanycytes play an important role in hypothalamic control of energy homeostasis, although this has not been directly tested. Here, we… read more here.
Keywords: median eminence; arcuate nucleus; nucleus median; mice ... See more keywords
Expression of glucagon-like peptide 1 receptor in neuropeptide Y neurons of the arcuate nucleus in mice
Sign Up to like & getrecommendations! Published in 2021 at "Brain Structure and Function"
DOI: 10.1007/s00429-021-02380-y
Abstract: Glucagon-like peptide 1 (GLP-1) and its agonists exert anorexigenic effect at least partly via acting on GLP-1 receptors (GLP-1R) in the arcuate nucleus (ARC). While the anorexigenic, proopiomelanocortin (POMC) neurons of the ARC were shown… read more here.
Keywords: like peptide; glp; glucagon like; npy neurons ... See more keywords
Individual variability in the size and organization of the human arcuate nucleus of the medulla
Sign Up to like & getrecommendations! Published in 2021 at "Brain Structure and Function"
DOI: 10.1007/s00429-021-02396-4
Abstract: The arcuate nucleus (Arc) of the medulla is found in almost all human brains and in a small percentage of chimpanzee brains. It is absent in the brains of other mammalian species including mice, rats,… read more here.
Keywords: size; variability; variability size; medulla ... See more keywords
Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.156
Abstract: Neuromedin U (NMU) has a precursor that contains one additional peptide consisting of 33 or 36 amino acid residues. Recently, we identified this second peptide from rat brain and designated it neuromedin U precursor-related peptide… read more here.
Keywords: secretion; neurons arcuate; prolactin; arcuate nucleus ... See more keywords
Oxyntomodulin induces satiety and activates the arcuate nucleus of the hypothalamus in Japanese quail.
Sign Up to like & getrecommendations! Published in 2020 at "Comparative biochemistry and physiology. Part A, Molecular & integrative physiology"
DOI: 10.1016/j.cbpa.2020.110721
Abstract: Oxyntomodulin (OXM) is a proglucagon-derived peptide that suppresses hunger in humans. There are some differences in its food intake-inhibitory effects among species. The central mechanisms are unclear and it is unknown if OXM is more… read more here.
Keywords: arcuate nucleus; japanese quail; physiology; injection ... See more keywords
Electrophysiological characterization of glucose sensing neurons in the hypothalamic arcuate nucleus of male rats
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.03.041
Abstract: The arcuate nucleus (ARC), located at the base of hypothalamus, contains two main populations of neurons involved in the regulation of food intake and energy expenditure. The NPY neurons are orexigenic and their activation stimulates… read more here.
Keywords: electrophysiological characterization; arcuate nucleus; glucose sensing; arc neurons ... See more keywords
Kisspeptin expression is decreased in the arcuate nucleus of hypothyroid female rats with irregular estrus cycles
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2016.11.005
Abstract: Insufficiency of thyroid hormones inhibits gonadotropin release and results in dysregulation of reproductive function, although the precise mechanism of this disrupted gonadotropin secretion remains unclear. Kisspeptin is a neuropeptide that strongly stimulates gonadotropin secretion and… read more here.
Keywords: estrus cycles; arcuate nucleus; irregular estrus; expression ... See more keywords
Growth Hormone Receptor Deletion Reduces the Density of Axonal Projections from Hypothalamic Arcuate Nucleus Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.03.037
Abstract: The arcuate nucleus (ARH) is an important hypothalamic area for the homeostatic control of feeding and other metabolic functions. In the ARH, proopiomelanocortin- (POMC) and agouti-related peptide (AgRP)-expressing neurons play a key role in the… read more here.
Keywords: arcuate nucleus; pomc; density; growth hormone ... See more keywords
Resveratrol promotes the arcuate nucleus architecture remodeling to produce more anorexigenic neurons in high-fat-diet-fed mice.
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition"
DOI: 10.1016/j.nut.2017.10.019
Abstract: OBJECTIVE Adult hypothalamic neurogenesis has been considered a central regulator of energy balance. Resveratrol (RSV), a natural polyphenol, influences the body fat mass and reduces the amount of adipose tissue. The present study was designed… read more here.
Keywords: arcuate nucleus; newborn cells; rsv; anorexigenic neurons ... See more keywords
41 Diet-induced alterations in the hypothalamic and arcuate nucleus transcriptome in prepubertal heifers
Sign Up to like & getrecommendations! Published in 2021 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv33n2ab41
Abstract: Early onset of puberty is a key trait underpinning economically efficient cattle production systems. Although prepubertal plane of nutrition has been positively associated with earlier onset of puberty, the underlying biochemical mechanisms remain unknown. The… read more here.
Keywords: plane; expression; arcuate nucleus; puberty ... See more keywords
Transcriptome profiling of kisspeptin neurons from the mouse arcuate nucleus reveals new mechanisms in estrogenic control of fertility
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113749119
Abstract: Significance The arcuate nucleus (ARC) of the mediobasal hypothalamus is critically involved in hormonal communication from ovary to brain. Negative estrogen feedback to kisspeptin synthesizing neurons of the ARC is a crucial determinant of hypothalamic… read more here.
Keywords: transcriptome profiling; kisspeptin; arcuate nucleus; fertility ... See more keywords