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   Articles with "areg" as a keyword



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A defect of amphiregulin release predicted longer survival independently of YAP expression in patients with pleural mesothelioma in the IFCT‐0701 MAPS phase 3 trial

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recommendations! Published in 2022 at "International Journal of Cancer"

DOI: 10.1002/ijc.33997

Abstract: The Hippo pathway effector YAP is dysregulated in malignant pleural mesothelioma (MPM). YAP's target genes include the secreted growth factor amphiregulin (AREG), which is overexpressed in a wide range of epithelial cancers and plays an… read more here.

Keywords: cell; expression; ifct 0701; pleural mesothelioma ... See more keywords
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Nuclear AREG affects a low‐proliferative phenotype and contributes to drug resistance of melanoma

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recommendations! Published in 2022 at "International Journal of Cancer"

DOI: 10.1002/ijc.34254

Abstract: AMPHIREGULIN (AREG) is a multifaceted molecule, which acts not only as an extracellular ligand for EGF receptor (EGFR), but also as an intracellular signaling molecule. It remains elusive, however, whether AREG has a tumor suppressive… read more here.

Keywords: areg affects; areg; resistance melanoma; nuclear areg ... See more keywords
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Targeting autocrine amphiregulin robustly and reproducibly inhibits ovarian cancer in a syngeneic model: roles for wildtype p53

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recommendations! Published in 2021 at "Oncogene"

DOI: 10.1038/s41388-021-01784-8

Abstract: Ovarian cancer (OvCA) remains one of the most devastating malignancies, but treatment options are still limited. We report that amphiregulin (AREG) can serve as an effective and safe pharmacological target in a syngeneic murine model.… read more here.

Keywords: areg; wildtype p53; syngeneic model; model ... See more keywords
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Th17 cell-derived amphiregulin promotes colitis-associated intestinal fibrosis through activation of mTOR and MEK in intestinal myofibroblasts.

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recommendations! Published in 2022 at "Gastroenterology"

DOI: 10.1053/j.gastro.2022.09.006

Abstract: BACKGROUND & AIMS Intestinal fibrosis is a significant complication of Crohn's disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not… read more here.

Keywords: th17 cells; expression; intestinal fibrosis; areg ... See more keywords
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Abstract 1844: Investigating the role of amphiregulin in breast cancer

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-1844

Abstract: Breast cancer is the most prevalent cancer in women worldwide and afflicts more than 3.1 million women in the US alone. The epidermal growth factor receptor (EGFR) is frequently overexpressed in breast cancer and is… read more here.

Keywords: areg; breast; breast cancer; mice ... See more keywords