A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00763-17
Abstract: ABSTRACT Arenaviruses are enveloped negative-strand RNA viruses that cause significant human disease. These viruses encode only four proteins to accomplish the viral life cycle, so each arenavirus protein likely plays unappreciated accessory roles during infection.… read more here.
Keywords: junv; jun virus; host; pkr ... See more keywords
DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007125
Abstract: Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed. Because arenavirus… read more here.
Keywords: type interferons; interferons favors; ddx3 suppresses; suppresses type ... See more keywords
Highly Diverse Arenaviruses in Neotropical Bats, Brazil
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DOI: 10.3201/eid2812.220980
Abstract: We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007–2011. We identified Tacaribe virus in 2 Artibeus sp. bats and a new arenavirus species in Carollia perspicillata bats that… read more here.
Keywords: arenaviruses neotropical; bats brazil; diverse arenaviruses; neotropical bats ... See more keywords