Rhodium(III)-Catalyzed Asymmetric Addition of Inert Arene C-H Bond to Aldehydes To Afford Enantioenriched Phthalides.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01052
Abstract: An asymmetric rhodium(III)-catalyzed Grignard-type addition of inert arene C-H bond to aldehydes is reported. It provides a new strategy for the synthesis of chiral 3-substituted phthalides in good yields (up to 87%) with high enantiomeric… read more here.
Keywords: addition inert; addition; iii catalyzed; arene bond ... See more keywords
Carboxylate breaks the arene C–H bond via a hydrogen-atom-transfer mechanism in electrochemical cobalt catalysis†
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc01898h
Abstract: Combined computational and experimental studies elucidated the distinctive mechanistic features of electrochemical cobalt-catalyzed C–H oxygenation. A sequential electrochemical–chemical (EC) process was identified for the formation of an amidylcobalt(iii) intermediate. The synthesis, characterization, cyclic voltammetry studies,… read more here.
Keywords: carboxylate; electrochemical cobalt; cobalt; mechanism ... See more keywords
Multiple annulations of inert C(sp2)-H bonds with alkynes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00172a
Abstract: Transition-metal catalyzed directing group (DG) assisted annulation of inert C-H bonds leads to the formation of complex molecular frameworks from readily accessible substrates. Thus, multiple annulation of less functionalized substrates with unsaturated species leads to… read more here.
Keywords: bonds alkynes; type involves; annulation; arene bond ... See more keywords