Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex.
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DOI: 10.1021/acs.orglett.9b02948
Abstract: While several trifluoromethylation reactions involving the electrochemical generation of CF3 radicals via anodic oxidation have been reported, the alternative cathodic, reductive radical generation has remained elusive. Herein, the first cathodic trifluoromethylation of arenes and heteroarenes… read more here.
Keywords: trifluoromethylation; triflyltriethylammonium complex; trifluoromethylation arenes; arenes heteroarenes ... See more keywords
Selective C-H trifluoromethoxylation of (hetero)arenes as limiting reagent
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DOI: 10.1038/s41467-020-16451-x
Abstract: Methods for direct C-H trifluoromethoxylation of arenes and heteroarenes are rare, despite the importance of trifluoromethoxylated compounds for pharmaceuticals, agrochemicals, and material sciences. Especially selective C-H trifluoromethoxylation of pyridines remains a formidable challenge. Here we… read more here.
Keywords: selective trifluoromethoxylation; trifluoromethoxylation arenes; trifluoromethoxylation; arenes heteroarenes ... See more keywords
Regioselective magnesiations of functionalized arenes and heteroarenes using TMP2Mg in hydrocarbons.
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DOI: 10.1039/d2cc03856k
Abstract: We report the preparation of a new hydrocarbon-soluble magnesium amide TMP2Mg (TMP = 2,2,6,6-tetramethylpiperidyl). This base showed excellent properties for the regioselective magnesiation of various arenes and heteroarenes bearing ethyl esters and carbamates under very… read more here.
Keywords: magnesiations functionalized; regioselective magnesiations; arenes heteroarenes; heteroarenes using ... See more keywords
Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow
Sign Up to like & getrecommendations! Published in 2020 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.16.111
Abstract: The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch… read more here.
Keywords: heteroarenes continuous; trifluoromethoxylation arenes; photocatalytic trifluoromethoxylation; continuous flow ... See more keywords