Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non–small cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aaf8223
Abstract: E6AP exhibits tumor suppressor activity that may help stratify NSCLC patients. INK4/ARF repression in lung cancer by loss of E6AP The abundance of the cell cycle decelerator p16INK4a, encoded at the INK4/ARF locus, is decreased… read more here.
Keywords: arf locus; expression; ink4 arf; lung cancer ... See more keywords
Transcriptional regulation of INK4/ARF locus by cis and trans mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.948351
Abstract: 9p21 locus is one of the most reproducible regions in genome-wide association studies (GWAS). The region harbors CDKN2A/B genes that code for p16INK4a, p15INK4b, and p14ARF proteins, and it also harbors a long gene desert… read more here.
Keywords: locus; arf locus; ink4 arf; transcriptional regulation ... See more keywords