ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.12.014
Abstract: Though significant progress has been made in the availability of diagnostic techniques and treatment strategies, pancreatic cancer remains a disease of high mortality rates. Therefore, there is an urgent need for a better understanding of… read more here.
Keywords: mutant kras; arf6; pancreatic cancer; warburg effect ... See more keywords
The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-3026
Abstract: Melanoma has an unusual capacity to spread in early-stage disease, prompting aggressive clinical intervention in very thin primary tumors. Despite these proactive efforts, patients with low-risk, low-stage disease can still develop metastasis, indicating the presence… read more here.
Keywords: activation; metastasis; melanoma; arf6 ... See more keywords
Abstract 3492: The small GTPase ARF6 augments BRAFV600E-MAPK signaling in melanomagenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3492
Abstract: ARF6 is a member of the Ras superfamily of small GTPases and has critical functions in endo-membrane trafficking pathways. We previously reported that ARF6 is aberrantly activated in metastatic melanoma and that activation of ARF6… read more here.
Keywords: brafv600e mapk; small gtpase; mapk signaling; arf6 augments ... See more keywords
The small GTPase ARF6 regulates GABAergic synapse development
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-019-0543-3
Abstract: ADP ribosylation factors (ARFs) are a family of small GTPases composed of six members (ARF1–6) that control various cellular functions, including membrane trafficking and actin cytoskeletal rearrangement, in eukaryotic cells. Among them, ARF1 and ARF6… read more here.
Keywords: arf6; regulates gabaergic; arf6 regulates; small gtpase ... See more keywords
The Small GTPase Arf6 Functions as a Membrane Tether in a Chemically-Defined Reconstitution System
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.628910
Abstract: Arf-family small GTPases are essential protein components for membrane trafficking in all eukaryotic endomembrane systems, particularly during the formation of membrane-bound, coat protein complex-coated transport carriers. In addition to their roles in the transport carrier… read more here.
Keywords: membrane tether; arf6; defined reconstitution; membrane tethering ... See more keywords