Different Roles of TP53 Codon 72 Polymorphism in Type 2 Diabetes and Its Complications: Evidence from a Case-Control Study on a Chinese Han Population
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s322840
Abstract: Objective The purpose of this study was to investigate the relationships between TP53 Pro72Arg (rs1042522) polymorphism and susceptibility to type 2 diabetes (T2DM) and its related complications. Methods The TP53 Pro72Arg polymorphism was genotyped by… read more here.
Keywords: study; type diabetes; polymorphism; t2dm patients ... See more keywords
Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23115993
Abstract: Two short arginine-containing tripeptides, H-Arg-Arg-Arg-OH (TP1) and Ac-Arg-Arg-Arg-NH2 (TP2), have been shown by the patch-clamp method to modulate the NaV1.8 channels of DRG primary sensory neurons, which are responsible for the generation of nociceptive signals.… read more here.
Keywords: receptor binding; ligand receptor; containing tripeptides; arg arg ... See more keywords
Synthesis of Arginase Inhibitors: An Overview
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics17010117
Abstract: Arginase (ARG) is a binuclear manganese-containing metalloenzyme that can convert L-arginine to L-ornithine and urea and plays a key role in the urea cycle. It also mediates different cellular functions and processes such as proliferation,… read more here.
Keywords: synthesis arginase; arginase; arginase inhibitors; arg arg ... See more keywords