A phase II study of HMB/Arg/Gln against oral mucositis induced by chemoradiotherapy for patients with head and neck cancer
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DOI: 10.1007/s00520-018-4175-4
Abstract: PurposeThis phase II trial assessed the clinical benefit of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine (HMB/Arg/Gln) for preventing chemoradiotherapy (CRT)-induced oral mucositis (OM) in patients with head and neck cancer (HNC).MethodsPatients with HNC receiving definitive or postoperative… read more here.
Keywords: patients head; arg gln; oral mucositis; cancer ... See more keywords
Abstract B38: Molecular mechanisms and therapeutic implications of argininosuccinate synthesis 1 regulation in targeted arginine- and glutamine-starvation cancer therapy
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DOI: 10.1158/1557-3265.tcm17-b38
Abstract: Argininosuccinate synthetase 1 (ASS1) is the rate-limiting enzyme that catalyzes the biosynthesis of arginine (Arg). Many malignant human tumors are auxotrophic for Arg because ASS1 is silenced. We previously demonstrated that ASS1 is a sensor… read more here.
Keywords: therapy; starvation; arg gln; cancer ... See more keywords