Hyperglycemia‐impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways
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DOI: 10.1016/j.ejphar.2018.11.027
Abstract: &NA; Diabetes‐induced vascular endothelial dysfunction has been reported to involve hyperglycemia‐induced increases in arginase activity. However, upstream mediators of this effect are not clear. Here, we have tested involvement of Rho kinase, ERK1/2 and p38… read more here.
Keywords: p38 mapk; impaired aortic; arginase activity; arg1 ... See more keywords
Profiling the L-arginine/arginase 1 metabolism in early and advanced atherosclerosis
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DOI: 10.1093/eurheartj/ehae666.3891
Abstract: Atherosclerosis is a chronic inflammatory disease and the primary underlying cause of cardiovascular disease (CVD). Recently, intracellular metabolic pathways have been identified as master switches of immune cell function and thus seem promising targets for… read more here.
Keywords: arg metabolism; atherosclerosis; arg1; metabolism ... See more keywords
Neutralization of NET-associated human ARG1 enhances cancer immunotherapy
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DOI: 10.1126/scitranslmed.abq6221
Abstract: Myeloid cells can restrain antitumor immunity by metabolic pathways, such as the degradation of l-arginine, whose concentrations are regulated by the arginase 1 (ARG1) enzyme. Results from preclinical studies indicate the important role of arginine… read more here.
Keywords: arg1; net associated; harg1; human arg1 ... See more keywords
Abstract 6811: IL-9 enhances lung tumor growth through intrinsic and ARG1-dependent transcriptomic changes in interstitial macrophages
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DOI: 10.1158/1538-7445.am2024-6811
Abstract: A defining characteristic of cancer is its ability to evade detection by immune cells through the generation of a myeloid cell-dependent immunosuppressive tumor microenvironment. Arginine is utilized by Arginase 1 (ARG1) or nitric oxide synthase… read more here.
Keywords: interstitial macrophages; arg1; lung tumor; tumor ... See more keywords
Arginase 1–Based Immune Modulatory Vaccines Induce Anticancer Immunity and Synergize with Anti–PD-1 Checkpoint Blockade
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DOI: 10.1158/2326-6066.cir-21-0280
Abstract: ARG1-targeting vaccines are shown to activate antitumor immunity and modulate the tumor microenvironment in multiple tumor models without causing toxicity. The anti-tumor effect of ARG1 vaccines was boosted by anti–PD-1 checkpoint blockade, highlighting potential use… read more here.
Keywords: immunity; anti checkpoint; tumor; checkpoint blockade ... See more keywords
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice.
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DOI: 10.1172/jci.insight.131355
Abstract: Efferocytosis, or phagocytic clearance of dead/dying cells by brain-resident microglia and/or infiltrating macrophages, is instrumental for inflammation resolution and restoration of brain homeostasis after stroke. Here, we identify the signal transducer and activator of transcription… read more here.
Keywords: microglia macrophage; arg1; inflammation resolution; stat6 arg1 ... See more keywords