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   Articles with "arg1" as a keyword



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Hyperglycemia‐impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways

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recommendations! Published in 2019 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2018.11.027

Abstract: &NA; Diabetes‐induced vascular endothelial dysfunction has been reported to involve hyperglycemia‐induced increases in arginase activity. However, upstream mediators of this effect are not clear. Here, we have tested involvement of Rho kinase, ERK1/2 and p38… read more here.

Keywords: p38 mapk; impaired aortic; arginase activity; arg1 ... See more keywords
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Neutralization of NET-associated human ARG1 enhances cancer immunotherapy

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recommendations! Published in 2023 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.abq6221

Abstract: Myeloid cells can restrain antitumor immunity by metabolic pathways, such as the degradation of l-arginine, whose concentrations are regulated by the arginase 1 (ARG1) enzyme. Results from preclinical studies indicate the important role of arginine… read more here.

Keywords: arg1; net associated; harg1; human arg1 ... See more keywords
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Arginase 1–Based Immune Modulatory Vaccines Induce Anticancer Immunity and Synergize with Anti–PD-1 Checkpoint Blockade

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recommendations! Published in 2021 at "Cancer Immunology Research"

DOI: 10.1158/2326-6066.cir-21-0280

Abstract: ARG1-targeting vaccines are shown to activate antitumor immunity and modulate the tumor microenvironment in multiple tumor models without causing toxicity. The anti-tumor effect of ARG1 vaccines was boosted by anti–PD-1 checkpoint blockade, highlighting potential use… read more here.

Keywords: immunity; anti checkpoint; tumor; checkpoint blockade ... See more keywords
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STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice.

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recommendations! Published in 2019 at "JCI insight"

DOI: 10.1172/jci.insight.131355

Abstract: Efferocytosis, or phagocytic clearance of dead/dying cells by brain-resident microglia and/or infiltrating macrophages, is instrumental for inflammation resolution and restoration of brain homeostasis after stroke. Here, we identify the signal transducer and activator of transcription… read more here.

Keywords: microglia macrophage; arg1; inflammation resolution; stat6 arg1 ... See more keywords