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   Articles with "arginase" as a keyword



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Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis.

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recommendations! Published in 2023 at "Journal of cellular biochemistry"

DOI: 10.1002/jcb.30403

Abstract: Activation of hepatic stellate cells (HSC) is a key event in the initiation of liver fibrosis. Activated HSCs proliferate and secrete excessive amounts of extracellular matrix (ECM), disturbing liver architecture and function, leading to fibrosis… read more here.

Keywords: arginase; expression increased; hsc activation; expression ... See more keywords
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Arginase Inhibitors: A Rational Approach Over One Century

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recommendations! Published in 2017 at "Medicinal Research Reviews"

DOI: 10.1002/med.21419

Abstract: Arginase (EC 3.5.3.1) is the bimanganese enzyme that converts L‐arginine into ornithine and urea. This enzyme was discovered more than a century ago and early α‐amino acids were identified as weak inhibitors. It was only… read more here.

Keywords: arginase inhibitors; arginase; century; rational approach ... See more keywords
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Relationship between arginase genes polymorphisms and preschool wheezing phenotypes

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recommendations! Published in 2020 at "Pediatric Pulmonology"

DOI: 10.1002/ppul.25202

Abstract: The association between arginase I (ARG1) and arginase II (ARG2) genes and asthma has been reported in previous studies, but associations between polymorphisms in ARG genes and preschool wheezing (PSW) phenotypes are still unknown. read more here.

Keywords: genes polymorphisms; relationship arginase; polymorphisms preschool; arginase ... See more keywords
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Catalytic mechanism of DcsB: Arginase framework used for hydrolyzing its inhibitor

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recommendations! Published in 2022 at "Protein Science"

DOI: 10.1002/pro.4338

Abstract: DcsB, an enzyme produced from the d‐cycloserine biosynthetic gene cluster, displays moderate similarity to arginase in the sequence and three‐dimensional structure. Arginase is a ubiquitous enzyme hydrolyzing l‐arginine to generate l‐ornithine and urea, whereas DcsB… read more here.

Keywords: arginase; dcsb; inhibitor; catalytic mechanism ... See more keywords
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Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans.

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recommendations! Published in 2019 at "Analytical biochemistry"

DOI: 10.1016/j.ab.2019.04.019

Abstract: l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT). AGAT also catalyzes the formation of guanidinoacetate (GAA) from Arg and glycine (Gly). GAA is converted to creatine (N-methyl guanidinoacetate) by… read more here.

Keywords: evidence lysine; arginase; harg; homoarginine ... See more keywords
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Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

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recommendations! Published in 2018 at "Cell metabolism"

DOI: 10.1016/j.cmet.2018.04.009

Abstract: Kidney cancer, one of the ten most prevalent malignancies in the world, has exhibited increased incidence over the last decade. The most common subtype is "clear cell" renal cell carcinoma (ccRCC), which features consistent metabolic… read more here.

Keywords: carcinoma; arginase; biosynthetic cofactor; pyridoxal phosphate ... See more keywords
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Human-based evidence for the therapeutic potential of arginase inhibitors in cardiovascular diseases.

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recommendations! Published in 2020 at "Drug discovery today"

DOI: 10.1016/j.drudis.2020.11.005

Abstract: Arginase is a ubiquitous enzyme that regulates polyamine- and nitric-oxide-requiring vascular functions. It is well-established that, in mammals, arginase overactivation contributes to endothelial dysfunction, a hallmark of cardiovascular diseases. The pharmacological potential of arginase inhibition… read more here.

Keywords: arginase inhibitors; human based; arginase; potential arginase ... See more keywords
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The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection.

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recommendations! Published in 2017 at "Immunobiology"

DOI: 10.1016/j.imbio.2017.05.012

Abstract: During an immune response inflammatory macrophages with their wide variety of effector mechanisms including the expression of inducible nitric oxide synthase play an important part in the defense against invading pathogens. The inflammatory phenotype requires… read more here.

Keywords: tnf; arginase; expression; absence tnf ... See more keywords
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Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I.

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recommendations! Published in 2018 at "Journal of the American College of Cardiology"

DOI: 10.1016/j.jacc.2018.05.052

Abstract: BACKGROUND Cardiovascular complications are major clinical problems in type 2 diabetes mellitus (T2DM). The authors previously demonstrated a crucial role of red blood cells (RBCs) in control of cardiac function through arginase-dependent regulation of nitric… read more here.

Keywords: induce endothelial; arginase; type diabetes; rbcs ... See more keywords
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Association between arginase-containing platelet-derived microparticles and altered plasma arginine metabolism in polycystic ovary syndrome.

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recommendations! Published in 2019 at "Metabolism: clinical and experimental"

DOI: 10.1016/j.metabol.2018.10.008

Abstract: BACKGROUND Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease associated with insulin resistance and increased risk of cardiovascular diseases. However, a biomarker for potential cardiovascular disease in PCOS patients is not available. MATERIALS… read more here.

Keywords: polycystic ovary; arginase; ovary syndrome; derived microparticles ... See more keywords
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Endothelial arginase 2 mediates retinal ischemia/reperfusion injury by inducing mitochondrial dysfunction

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recommendations! Published in 2021 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2021.101273

Abstract: Objective Retinal ischemic disease is a major cause of vision loss. Current treatment options are limited to late-stage diseases, and the molecular mechanisms of the initial insult are not fully understood. We have previously shown… read more here.

Keywords: retinal ischemia; cell; arginase; ischemia reperfusion ... See more keywords