Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12221
Abstract: Abstract Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH. However, there is evidence that l‐citrulline might increase… read more here.
Keywords: arginase activity; hypoxic; nitric oxide; citrulline ... See more keywords
A serum metabolomics signature of hypothermia fatalities involving arginase activity, tryptophan content, and phosphatidylcholine saturation
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-018-1937-y
Abstract: IntroductionHypothermia is a potentially lethal condition whose postmortem diagnosis is often complex to perform due to the absence of pathognomonic lesions and biomarkers. Our first study of human serum and urinary metabolome in hypothermia fatalities… read more here.
Keywords: hypothermia; serum; arginase activity; signature hypothermia ... See more keywords
Hyperglycemia‐impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.11.027
Abstract: &NA; Diabetes‐induced vascular endothelial dysfunction has been reported to involve hyperglycemia‐induced increases in arginase activity. However, upstream mediators of this effect are not clear. Here, we have tested involvement of Rho kinase, ERK1/2 and p38… read more here.
Keywords: p38 mapk; impaired aortic; arginase activity; arg1 ... See more keywords
The changes in semen quality, arginase activity and nitric oxide level in dexamethasone‐treated rams
Sign Up to like & getrecommendations! Published in 2019 at "Andrologia"
DOI: 10.1111/and.13464
Abstract: This study was made to investigate the effects of intramuscular administrations of dexamethasone on seminal plasma nitric oxide levels and arginase activity, and some spermatological parameters in rams. Ten Akkaraman rams weighing 50–60 kg and… read more here.
Keywords: activity nitric; arginase activity; oxide level; nitric oxide ... See more keywords
Elevated levels of arginase activity are related to inflammation in patients with COPD exacerbation
Sign Up to like & getrecommendations! Published in 2021 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-021-01629-w
Abstract: Introduction Within the pathogenesis of the chronic obstructive pulmonary disease (COPD) there are interactions between different inflammatory mediators that are enhanced during an exacerbation. Arginase is present in bronchial epithelial cells, endothelial, fibroblasts and alveolar… read more here.
Keywords: arginase activity; exacerbation; inflammation; patients copd ... See more keywords
Inhibition of Host Arginase Activity Against Staphylococcal Bloodstream Infection by Different Metabolites
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01639
Abstract: Staphylococcus aureus is a notorious bacterial pathogen that often causes soft tissue and bloodstream infections and invariably garners resistance mechanisms against new antibiotics. Modulation of the host immune response by metabolites is a powerful tool… read more here.
Keywords: host arginase; arginase; arginase activity; bloodstream infection ... See more keywords
Markers of Endothelial Dysfunction Are Attenuated by Resveratrol in Preeclampsia
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11112111
Abstract: Preeclampsia (PE) is characterized by great endothelial dysfunction, decreased nitric oxide (NO) bioavailability, and higher levels of arginase activity. In the present study, we investigated the potential modulatory effects of trans-resveratrol (RSV) on arginase and… read more here.
Keywords: umbilical arteries; endothelial cells; dysfunction biomarkers; dysfunction ... See more keywords
Arginase Activity in Eisenia andrei Coelomocytes: Function in the Earthworm Innate Response
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22073687
Abstract: Arginase is the manganese metalloenzyme catalyzing the conversion of l-arginine to l-ornithine and urea. In vertebrates, arginase is involved in the immune response, tissue regeneration, and wound healing and is an important marker of alternative… read more here.
Keywords: wound healing; response; arginase activity; eisenia andrei ... See more keywords