Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance
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DOI: 10.1038/s41598-018-22099-x
Abstract: The inhibition of arginase, resulting in higher arginine (ARG) availability for nitric oxide synthesis, may account for the putative protective effect of homoarginine (HOMOARG) against atherosclerosis and cardiovascular disease. However, uncertainty exists regarding the significance… read more here.
Keywords: arginase; homoarg; inhibition; homoarginine ... See more keywords
Effects of arginase inhibition on myocardial Ca2+ and contractile responses
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DOI: 10.14814/phy2.15396
Abstract: Nitric oxide (NO) is thought to increase cardiac contractility by increasing cytosolic Ca2+ concentration ([Ca2+]cyt) during excitation. Alternatively, NO could increase the sensitivity of the contractile response to [Ca2+]cyt (Ca2+ sensitivity). Arginase regulates NO production… read more here.
Keywords: ca2 cyt; sensitivity; ca2; arginase inhibition ... See more keywords
Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated N-arylcinnamamides
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DOI: 10.3390/ijms24043611
Abstract: A series of seventeen 4-chlorocinnamanilides and seventeen 3,4-dichlorocinnamanilides were characterized for their antiplasmodial activity. In vitro screening on a chloroquine-sensitive strain of Plasmodium falciparum 3D7/MRA-102 highlighted that 23 compounds possessed IC50 < 30 µM. Typically,… read more here.
Keywords: arginase; towards arginase; hybrid sar; inhibition hybrid ... See more keywords