Arginase Inhibitors: A Rational Approach Over One Century
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DOI: 10.1002/med.21419
Abstract: Arginase (EC 3.5.3.1) is the bimanganese enzyme that converts L‐arginine into ornithine and urea. This enzyme was discovered more than a century ago and early α‐amino acids were identified as weak inhibitors. It was only… read more here.
Keywords: arginase inhibitors; arginase; century; rational approach ... See more keywords
Human-based evidence for the therapeutic potential of arginase inhibitors in cardiovascular diseases.
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DOI: 10.1016/j.drudis.2020.11.005
Abstract: Arginase is a ubiquitous enzyme that regulates polyamine- and nitric-oxide-requiring vascular functions. It is well-established that, in mammals, arginase overactivation contributes to endothelial dysfunction, a hallmark of cardiovascular diseases. The pharmacological potential of arginase inhibition… read more here.
Keywords: arginase inhibitors; human based; arginase; potential arginase ... See more keywords