Loop engineering reveals the importance of active-site-decorating loops and gating residue in substrate affinity modulation of arginine deiminase (an anti-tumor enzyme).
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.134
Abstract: Protein engineering of enzyme loop regions is an effective strategy to improve enzymatic properties. Previous studies that aimed to boost the activity of PpADI (an arginine deiminase from Pseudomonas plecoglossicida) under physiological conditions yielded several… read more here.
Keywords: substrate affinity; active site; arginine deiminase; site ... See more keywords
The effect of starters with a functional arginine deiminase pathway on cheese ripening and quality
Sign Up to like & getrecommendations! Published in 2018 at "International Dairy Journal"
DOI: 10.1016/j.idairyj.2018.05.008
Abstract: Abstract The arginine deiminase (ADI) pathway catalyses the degradation of l -arginine via the intermediate l -citrulline into l -ornithine, ammonia, and CO2. This constitutes an important metabolic feature of some lactic acid bacteria (LAB)… read more here.
Keywords: arginine deiminase; adi pathway; pathway; ripening quality ... See more keywords
Thermostability and Specific-Activity Enhancement of an Arginine Deiminase from Enterococcus faecalis SK23.001 via Semirational Design for l-Citrulline Production.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b02858
Abstract: l-Citrulline is a nonessential amino acid with a variety of physiological functions and can be enzymatically produced by arginine deiminase (ADI, EC 3.5.3.6). The enzymatic-production approach is of immense interest because of its mild conditions,… read more here.
Keywords: faecalis sk23; sk23 001; thermostability; arginine deiminase ... See more keywords
Development of a Selective Inhibitor of Protein Arginine Deiminase 2.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00274
Abstract: Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective inhibitor has been developed. Such a compound will be… read more here.
Keywords: protein arginine; selective inhibitor; arginine deiminase;
Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00283
Abstract: Protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the conversion of arginine to citrulline within target proteins. Dysregulation of PAD4 has been implicated in a number of human diseases, including rheumatoid arthritis… read more here.
Keywords: pad4 inhibitor; pad4; protein arginine; arginine deiminase ... See more keywords
Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17066-y
Abstract: Protein arginine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H3 and H4. While the precise epigenetic function of this modification has not been resolved, it has been shown to associate with… read more here.
Keywords: pad4; protein arginine; arginine deiminase; glycation ... See more keywords
Acquisition of the arginine deiminase system benefits epiparasitic Saccharibacteria and their host bacteria in a mammalian niche environment
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114909119
Abstract: Significance The Candidate Phyla Radiation (CPR) is a large monophyletic lineage with poorly understood biology. Saccharibacteria are ultrasmall parasitic CPR bacteria with highly reduced genomes that have made the transition from an environmental origin to… read more here.
Keywords: environment; arginine deiminase; deiminase system; niche ... See more keywords
A virulence factor as a therapeutic: the probiotic Enterococcus faecium SF68 arginine deiminase inhibits innate immune signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2106105
Abstract: ABSTRACT The probiotic bacterial strain Enterococcus faecium SF68 has been shown to alleviate symptoms of intestinal inflammation in human clinical trials and animal feed supplementation studies. To identify factors involved in immunomodulatory effects on host… read more here.
Keywords: arginine deiminase; enterococcus; faecium sf68; sf68 ... See more keywords
Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers
Sign Up to like & getrecommendations! Published in 2021 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.1943253
Abstract: ABSTRACT Background Pegylated arginine deiminase (ADI-PEG 20) is a metabolism-based strategy that depletes arginine, resulting in tumoral stress and cytotoxicity. Preclinically, ADI-PEG 20 modulates T-cell activity and enhances the therapeutic efficacy of programmed death-1 (PD-1)… read more here.
Keywords: pembrolizumab; peg; adi peg; pegylated arginine ... See more keywords
Polymorphism of protein tyrosine phosphatase non‐receptor type 22 and protein arginine deiminase 4 gene among Ghanaian rheumatoid arthritis patients: A case–control study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14348
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease which affects millions of lives globally characterized by chronic inflammation in the joints of the body. There is no known cause for RA; however, genetic predisposition has been… read more here.
Keywords: protein tyrosine; protein arginine; arginine deiminase; rheumatoid arthritis ... See more keywords
Arginine Deiminase Induces Immunogenic Cell Death and Is Enhanced by N-acetylcysteine in Murine MC38 Colorectal Cancer Cells and MDA-MB-231 Human Breast Cancer Cells In Vitro
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26020511
Abstract: The use of arginine deiminase (ADI) for arginine depletion therapy is an attractive anticancer approach. Combination strategies are needed to overcome the resistance of severe types of cancer cells to this monotherapy. In the current… read more here.
Keywords: arginine deiminase; cancer cells; cancer; adi peg ... See more keywords