Degradation of AMPK‐α1 sensitizes BRAF inhibitor‐resistant melanoma cells to arginine deprivation
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DOI: 10.1002/1878-0261.12151
Abstract: Melanomas harboring BRAF mutation (V600E) are known to recur frequently following treatment with BRAF inhibitors (BRAFi) despite a high initial response rate. Our previous study has uncovered that BRAFi‐resistant melanoma (BR) cells are vulnerable to… read more here.
Keywords: melanoma cells; arginine deprivation; degradation ampk;
Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes
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DOI: 10.1038/s41598-018-30591-7
Abstract: Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy. Here, we show that colorectal cancers (CRCs) display negligible… read more here.
Keywords: deprivation therapy; urea cycle; arginine deprivation; deprivation ... See more keywords
Abstract PR03: Arginine deprivation as a potential targeted therapy for clear cell ovarian carcinoma
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DOI: 10.1158/1557-3265.ovca17-pr03
Abstract: In this study, we explored the metabolic pathways of clear cell ovarian carcinoma (CCOC) and the therapeutic importance of aberrant arginine metabolism in this cancer. In 2017, an estimated 22,440 women will be diagnosed with… read more here.
Keywords: ccoc; arginine deprivation; therapy; cell ... See more keywords
Bench-to-Bedside Studies of Arginine Deprivation in Cancer
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DOI: 10.3390/molecules28052150
Abstract: Arginine is a semi-essential amino acid which becomes wholly essential in many cancers commonly due to the functional loss of Argininosuccinate Synthetase 1 (ASS1). As arginine is vital for a plethora of cellular processes, its… read more here.
Keywords: bench bedside; arginine deprivation; deprivation; adi peg20 ... See more keywords